• The feasibility of interspecific rescue of endothelial/hematopoietic lineage deficiency 

    Zhao, Chongbei (University of Missouri--Columbia, 2012)
    Here we propose to develop a mouse model which will establish “proof of principle” for future development of large animal (e.g. pig) models which could be used as actual human solid organ and blood donors as well as in ...
  • Genetic linkage of multiple modifications in the pig 

    Beaton, Benjamin Paul (2015)
    Genetic engineering facilitates heritable modification of target genomes. Modifications can be site-specific or random. Though inefficient, homologous recombination allows for precise genome modification. Random integration ...
  • GGTA-1 targeting efficiency with a xenograft transgene 

    Beaton, Benjamin (University of Missouri--Columbia, 2012)
    Gene targeting by homologous recombination was utilized to target the GGTA-1 locus. Two independent enrichment strategies were evaluated to determine if targeting efficiencies at the GGTA-1 locus could be improved. The ...