Browsing by Thesis Advisor "Wyckoff, Gerald J."
Now showing items 1-7 of 7
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A Method for Identification of Pancreatic Cancer through Methylation Signatures in Cell-Free DNA
(2022)Pancreatic cancer has high mortality rates in comparison to other cancers due to limited treatment options and challenges in detecting the disease. Early diagnosis is difficult; successful outcomes are directly tied to ... -
Calculating the structure-based phylogenetic relationship of distantly related homologous proteins utilizing maximum likelihood structural alignment combinatorics and a novel structural molecular clock hypothesis
(2013)Dendrograms establish the evolutionary relationships and homology of species, proteins, or genes. Homology modeling, ligand binding, and pharmaceutical testing all depend upon the homology ascertained by dendrograms. ... -
Characterization of 5-methylcytosine dioxygenase Tet2 and rescue of mutant Tet2 activity by using turbo co-substrate
(2023)Regulation of epigenetic transcription mediated by 5-methylcytosine (5mC) plays a critical role in eukaryotic development. Demethylation of these epigenetic marks is accomplished by sequential oxidation by ten-eleven ... -
Extinction of Chromosomes due to Specialization is a Universal Occurrence
(2019)The human X and Y chromosomes evolved from a pair of autosomes approximately 180 million years ago. Despite their shared evolutionary origin, extensive genetic decay has resulted in the human Y chromosome losing 97% of its ... -
Functional Sorting of Evolutionary Effects in Protein Domains
(University of Missouri--Kansas City, 2010)One of the most important questions in evolutionary genetics is whether a gene of interest is under positive selection, negative selection or neutral evolution. Although there are numerous existed methods and statistical ... -
Hyper-Plastic Structural Evolution Of The PEX Domain - A Model Of Evolutionary Exaptation And Neofunctionalization At The Molecular Level
(University of Missouri--Kansas City, 2017)With the advent of sophisticated genetic, biophysical and in silico technology an enormous amount of information is being generated regarding the structural, biochemical and physiological aspects of proteins. Tertiary ... -
Novel nanocarriers to improve drug delivery for age-related macular degeneration
(2021)Visual impairment affecting the posterior segment of the eye is a significant health problem causing a deterioration of the quality of life of millions worldwide. Age-related macular degeneration (AMD) is ranked third on ...