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Development of model systems for the vector-host-pathogen interface of bubonic plague
(University of Missouri--Columbia, 2013)
Bubonic plague infections begin in the dermis when the pathogen is introduced by a flea during a routine blood feed. Several barriers separate Yersinia pestis from its replicative niche, including phagocytic cells in the ...
Factors contributing to humoral immunity against pneumonic plague
(University of Missouri--Columbia, 2012)
Yersinia pestis is the etiologic agent of plague and is responsible for more human deaths throughout history than any other bacterial pathogen. During infection bacteria inject effector proteins into target host cells using ...
Inflammatory and cardiac response to end-stage pneumonic plague
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Yersinia pestis is the etiologic agent of pneumonic plague, a devastating disease in humans characterized by acute bronchopneumonia that is frequently ...
Versinia pestis YopJ, YopT, and YopK coordinate programmed cell death and cytokine responses to promote pneumonic plague
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Yersinia pestis has been responsible for three major pandemics of plague, including the infamous Black Death that killed 250 million people in Europe. ...
Protection from pneumonic plague by the induction of heme oxygenase-1
(University of Missouri--Columbia, 2018)
Yersinia pestis is the etiological agent of the disease known as plague. The pathology of this disease is characterized by organ failure due to necrosis and hyperinflammation towards the end of the disease. However, Y. ...
Characterization of the pigmentation locus in Yersinia pestis pathogenesis of pneumonic plague
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The extreme virulence of Yersinia pestis in all three forms of plague disease is attributed to its multiple virulence factors. Y. pestis pathogenesis ...
Yersinia pestis YopK contributes to immune evasion and cell death to promote plague
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] YopK is a 21-kilodalton protein that is secreted and translocated by the type three secretion system of Yersinia pestis, the causative agent of pneumonic, ...
Activation and evasion of innate immune signaling pathways by Yersinia pestis
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Yersinia pestis is a bacterial pathogen that causes the disease plague in mammals. The disease is rapidly lethal and infected individuals can succumb ...