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Development of advanced chemometric methods for analysis of deep-ultraviolet resonance Raman and circular dichroism spectroscopic data for protein secondary structure determination
(University of Missouri--Columbia, 2015)
Determination of protein secondary structure has become an area of great importance in biochemistry and biophysics as protein secondary structure is directly related to protein function and protein related diseases. While ...
Spectroscopic distinguishability, forced degradation kinetics and lc-ms/ms degradation product characterizations involving 5-fluorouracil and similar or affiliated compounds in relation to environmental concerns
(University of Missouri--Columbia, 2015)
5-Fluorouracil (5-FU) is a commonly used antiviral and anticancer drug. 5-FU is believed to exist in various tautomeric forms, which are believed to contribute to 5-FU's cytotoxicity. In order to understand the activity ...