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Protein transport : bioinformatics methods for understanding protein subcellular localization
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Eukaryotic cells contain diverse subcellular organelles. These organelles form distinct functional cellular compartments where different biological ...
Complexity reduction and visualization tool for RDF knowledge network application in precision medicine
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Precision medicine is one of the most rapidly emerging areas of research and development, crucial for improving patient care, but there is a lack of ...
Data analysis and prediction of protein posttranslational modification
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Protein posttranslational modification (PTM) occurs broadly after or during protein biosynthesis, to assist folding or activate function during the ...
Computational analysis of tongue image for health diagnosis
(University of Missouri--Columbia, 2017)
Tongue, the primary taste organ in the mouth, can reflect the whole body's health conditions based on the Traditional Chinese Medical (TCM) theories. Watching the tongue is one of the most common, essential and reliable ...
Applications of deep neural networks to protein structure prediction
(University of Missouri--Columbia, 2018)
Protein secondary structure, backbone torsion angle and other secondary structure features can provide useful information for protein 3D structure prediction and protein functions. Deep learning offers a new opportunity ...
Large-scale soybean genome-wide variation workflow and association analysis using deep learning
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] With the advances in next-generation sequencing technology and significant reduction in sequencing costs, it is now possible to sequence large collections ...
Genome scale meta analysis of microarrays for biological inferences
(University of Missouri--Columbia, 2009)
In this present era of high-throughput technologies, meta-analysis is being widely used to integrate multiple similar high throughput studies. Here we propose a novel framework for applying meta-analysis techniques on ...
A novel framework for protein structure prediction
(University of Missouri--Columbia, 2007)
Proteins are one of the most important molecules in the life processes. The structure of a protein is essential in understanding the function of a protein at the molecular level. Due to rapid progress in sequencing ...
Bioinformatics methods for protein identification using peptide mass fingerprinting data
(University of Missouri--Columbia, 2009)
Protein identification using mass spectrometry is an important yet partially solved problem in the study of proteomics during the post-genomic era. The major techniques used in mass spectrometry are Peptide Mass Fingerprinting ...
Bioinformatics analysis and prediction of protein phosphorylation and other posttranslational modifications
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Protein posttranslational modifications (PTM), such as phosphorylation, play essential roles in many aspects of cell life. With the rapid accumulation ...
Protein structural models selection using 4-mer sequence and combined single and consensus scores
(University of Missouri--Columbia, 2012)
Quality assessment for protein structure models is an important issue in protein structure prediction. Consensus methods assess each model based on its structural similarity to all the other models in a model set, while ...
Development of a plant protein phosphorylation database and a web-based protein phosphorylation prediction tool
(University of Missouri--Columbia, 2012)
In this project, two efficient and intuitive user-interfaces were designed and developed to be highly accessible and versatile for bioinformatics researchers. Two web based user interfaces were designed for two bioinformatics ...
Development of Soybean Knowledge Base (SoyKB), a multi-omics data integration web resource for bridging molecular breeding and translational genomics in Glycine Max
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Many genome-scale data are available in soybean (Glycine Max) including genomics, transcriptomics, proteomics and metabolomics datasets, together with ...
PRIMEGENSv2 : a service based platform using object oriented model view controller design pattern
(University of Missouri--Columbia, 2009)
There are a number of tools and software packages dealing with the problem of efficient primer and probe design. In an era of fast paced research it is rather difficult for any researcher to change their favorite tool. So ...
Genome-wide microbial phylogeny reconstruction with polytomy identification
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Evolutionary comparative genomics is one of the most studied areas in the computational biology. With ever increasing speed of newly sequenced microbial ...
Development of tools for SoyKB: SNPViz, differential expression and protein bioviewer
(University of Missouri--Columbia, 2014)
Soybean Knowledge Base (SoyKB) is a comprehensive website, which contains lots of web sources for soybean. By integrating multi omics data and solving data storage problem, SoyKB is able to build connection between multiple ...
Computational methods for bacterial characterization and bacteria-host/environment interaction analyses
(University of Missouri--Columbia, 2012)
With the rapid development of next-generation sequencing technologies, bacterial identification becomes a very important and essential step in processing genomic data, especially for metagenomic data. Many computational ...
Develpment of soybean knowledge base for systems biology studies
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Soybean (Glycine max), as an important crop worldwide primarily for protein and oil, has raised great interest in both basic and applied researches. ...
Methods for protein structure prediction
(University of Missouri--Columbia, 2014)
Using pathway correlation profiles for understanding pathway perturbation
(University of Missouri--Columbia, 2012)
Identifying perturbed or dysregulated pathways is critical to understanding the biological processes that change within an experiment. Previous methods identified important pathways that are significantly enriched among ...