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The role of sphingosine kinase in influenza virus mediated inflammasome activitation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Influenza viruses continue to pose a grave burden on the global health and economy. Dysregulated innate immune system can lead to rapid infiltration ...
Sphingosine analog AAL-R enhances dendritic cell responses upon TLR7 ligation [abstract]
(2010)
Sphingosine analogs display immune suppressive activities and thus have therapeutic potential in the treatment of autoimmune diseases. In this study, we investigated the effect of a sphingosine analog, AAL-R, on the host ...
The role of sphingosine 1-phosphatemetabolizing enzymes in host defense to RNA virus infections
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Viruses are intracellular parasites that rely on the host cell machinery to effectively replicate themselves and spread within the host to cause ...
Virus interactions with the sphingolipid network : sphingosine kinase 2 in immunosuppression, immunopathology, and viral propagation
(University of Missouri--Columbia, 2020)
Sphingosine 1-phosphate (S1P) is a bioactive lipid molecule known to regulate diverse cellular functions. S1P is metabolized by the sphingosine kinases (SphK) and S1P lyase (SPL). However, little is known about the role ...
Influenza virus strategies to regulate S1P-metabolizing enzymes and evade host innate immunity for robust viral replication
(University of Missouri--Columbia, 2021)
Viral infection is a complex network of interactions involving the host defending itself against the virus and the virus attempting to subdue host defenses and utilize the cellular machinery to promote its replication. ...