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Optimal designs for dose-finding in contingent response models
(University of Missouri--Columbia, 2004)
We study D- and c-optimal designs for dose-finding with opposing failure functions. In particular, we study the contingent response models of Li, Durham and Flournoy (1995). In the contingent response model, there are two ...
Adaptive optimal design with application to a two drug combination trial based on efficiency-toxicity response
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The first part of this dissertation develops an adaptive optimal design for dose-finding with combination therapies that accounts for both efficacy ...