Now showing items 1-3 of 3
Gating of CFTR chloride channels : distinct closed states revealed by the action of AMP-PNP
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The CFTR chloride channel is gated by ATP through an irreversible gating cycle driven by an input of free energy of ATP hydrolysis. The open state of ...
CFTR chloride channels and ABC active transporters undergo similar structural rearrangements as part of their operation
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Defects in the cystic fibrosis transmembrane conductance regulator (CFTR) underlie the lethal genetic disease cystic fibrosis. Although CFTR belongs ...
Structure/function studies of CFTR's pore-forming domain reveal evolutionary divergence between CFTR and ABC transporters
(University of Missouri--Columbia, 2015)
Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is the culprit behind Cystic Fibrosis (CF), a genetic disease highly occurs among Caucasians. Studying the structure/function of CFTR chloride channel not only ...