Now showing items 1-2 of 2
The roles of ERK pathway localization and the regulation of [beta]-catenin/Bcl-XL kinetic in thymic selection
(University of Missouri--Columbia, 2011)
Thymocytes undergo a process of development that serves to favor the differentiation of T-cells bearing self-MHC (major histo-compatibility complex) restricted T-cell receptors (TCR). Signaling through the TCR is crucial ...
The scaffold protein POSH regulates T lymphocyte function
(University of Missouri--Columbia, 2015)
T lymphocytes are critical mediators of the adaptive immune response. T cell receptor (TCR) mediated cJUN NH2-terminal kinase (JNK) activation is required for mounting proper T cell mediated immune responses. However, ...