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Pupillary Light Reflex Deficits in a Canine Model of Neuronal Ceroid Lipofuscinosis and the Effects of Enzyme Replacement Therapy
(University of Missouri--Columbia, 2013)
Pupil size is controlled by the autonomic nervous system, and iris behavior reflects a balance of input from both the sympathetic and parasympathetic nervous systems. The pupillary light reflex (PLR) occurs in response to ...
Motor unit characterization in canine degenerative myelopathy :a disease model for amyotrophic lateral sclerosis
(University of Missouri--Columbia, 2013)
Dogs homozygous for missense mutations in superoxide dismutase 1 (SOD1) develop a late-onset neuromuscular disorder called degenerative myelopathy (DM) that has many similarities to amyotrophic lateral sclerosis (ALS). ...
Ex vivo gene therapy for the preservation of retinal and central nervous system structure and function in a canine model of CLN2 neuronal ceroid lipofuscinosis
(University of Missouri--Columbia, 2016)
The neuronal ceroid lipofuscinoses (NCLs) are an inherited group of related lysosomal storage disorders. The NCLs are characterized in general by the accumulation of autofluorescent lysosomal storage material (ceroid-type ...