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The effect of mGluR7 antagonist treatment on a dopamine-induced murine model of obsessive-compulsive disorder
(University of Missouri--Columbia, 2016)
Obsessive-compulsive disorder (OCD) is an incapacitating anxiety disorder characterized by unwanted, intrusive thoughts that lead to repetitive, ritualistic behaviors. Current treatments for OCD are only efficacious in a ...
The effect of estrogen deficiency on learning and memory in two novel rat models of Alzheimer's disease
(University of Missouri--Columbia, 2017)
Alzheimer's disease is a progressive neurodegenerative disorder that results in synaptic and neuronal loss in regions of the brain responsible for memory and cognition. To date, transgenic animal models have played a crucial ...
Precision and capacity development in auditory working memory
(University of Missouri--Columbia, 2014)
This research has explored the development of auditory working memory capacity and precision in children and adults. Very little is known about the capacity limits of auditory working memory, and even less is known about ...
CDPPB reverses an NMDA receptor antagonist-induced deficit in inhibitory avoidance and conditioned taste aversion learning in rats
(University of Missouri--Columbia, 2010)
Rats administered a metabotropic glutamate receptor 5 (mGluR5) positive allosteric modulator (PAM), CDPPB, and/or an NMDA receptor antagonist, MK-801, were given inhibitory avoidance or conditioned taste aversion training. ...
The effects of an mGluR7 agonist, AMN082, on conditioned taste aversion
(University of Missouri--Columbia, 2010)
Metabotropic glutamate receptors impact learning and memory. The current studies examined the effects of AMN082, a recently discovered selective metabotropic glutamate receptor 7 (mGluR7) allosteric agonist, on the acquisition ...
Impaired spatial learning and increased locomotor activity in TgCRND8 mice as a model of Alzheimer's disease
(University of Missouri--Columbia, 2010)
This study provides a behavioral characterization of the TgCRND8 mouse strain, an APP (double-mutant) transgenic model of Alzheimer's disease (AD). While past research focused mainly on 2-5 month-old TgCRND8 mice, this ...
EGCG and voluntary exercise : an examination of treatment effects using the TgCRND8 mouse model of Alzheimer's disease
(University of Missouri--Columbia, 2013)
Previous work with the TgCRND8 mouse model of Alzheimer's disease has shown that voluntary exercise implemented for long time periods (5-months) and starting at very young ages (1-month), prior to the development of disease ...
Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning in rodents
(University of Missouri--Columbia, 2012)
Metabotropic glutamate receptor 5 (mGlu5) has been implicated in a variety of learning processes and is important for aversive learning tasks. The present studies used an mGlu5 receptor positive allosteric modulator, ...
The effect of mGluR2 3 agonist, LY379268, and a mGluR4 positive allosteric modulator, VU0155041, on conditioned taste aversion
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Metabotropic glutamate (mGlu) receptors are known to mediate learning and memory. Although evidence indicates a role for mGlu receptors (e.g., mGlu5) ...
Associative learning and thiamine based flavor preference
(University of Missouri--Columbia, 2015)
The current experiment explored the extent to which thiamine deficiency at the time of conditioning is important as well as the importance of thiamine deficiency at the time of testing. This experiment controlled for ...