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Analysis of Obesity (ob/ob) and Diabetes (db/db) Mutation Syndromes on Hypothalamic Medial Basal Nucleic Neuronal Degeneration in C57BL/Ks] Mice
(University of Missouri--Kansas City, 4/30/2013)
The influence of the diabetes (db/db) and obese (Db/Db) genetic mutations on the hypothalamic medial basal nuclei neuronal structure was studied in C57BLIKsJ mice strains by morphometric analysis of medial basal nuclei ...
Inhibition of Phosphorylated Serine 522 Beta-Catenin in Leukemia Stem Cells
Mutations in the Wingless (Wnt)1 p-catenin and the Phosphatidylinositol 3-Kinase (PI3K)lProtein Kinase B (Akt) protein signaling pathways are prevalent in several types of cancers. Cooperative interaction between the ...
Development of methodology for performing coupled assays of ATP utilization under halophilic (high salt) conditions
(University of Missouri--Kansas City, 5/6/2013)
Archaea are an evolutionarily distinct domain of organisms that use isoprenoid compounds in the synthesis of their lipid membranes. Haloferax enzymes involved in the biochemical pathway (mevalonate pathway) responsible ...
Reproducibility in high-throughput mutagenesis and gene expression analysis
(University of Missouri--Kansas City, 2016-05)
In Saccharomyces cerevisiae, meiosis is controlled by expression of the IME1 gene. To examine, how IME1 is regulated, ~ 100 mutants were constructed, each containing a different point mutation in the promoter of this gene ...
Implications of β-hydroxy-β-methylbutyrate (HMB) Supplementation on Expression of Key Regulatory Genes during C2Cl2 Myoblast Differentiation
(University of Missouri--Kansas City, 2014-05)
The development, growth, and maintenance of muscle mass and function during life is essential for optimal health. Therefore, studying the cellular and molecular mechanisms that control this process is required for the ...