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Immunomodulators in feline asthma
(University of Missouri--Columbia, 2010)
Experimental asthma was induced in 10 cats using Bermuda grass allergen (BGA) and cats were randomly selected to receive either feG (1 mg/kg, PO) or saline for 2 weeks, followed by a 2 week washout period before receiving ...
Pathogenicity of Helicobacter ganmani infection in Helicobacter susceptible and resistant mice
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Helicobacter species are one of the most prevalent bacterial contaminants of laboratory rodents. It is currently unknown whether Helicobacter ganmani, ...
The role of spontaneous bursts of muscle sympathetic nerve activity in mediating peripheral vascular responses and cardiovascular hemodynamics in resting man
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The ability for sympathetic nerve activity to dynamically evoke vasoconstriction is paramount for the regulation of blood flow and blood pressure. ...
6-Thioguanine and zebularine globally demethylate a canine lyphoma cell line
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Epigenetic modifications of chromatin, including methylation, histone modifications, and protein chaperoning, play a significant role in the biology ...
Vascular actions of insulin in cardiometabolic disease : effects of metformin, physical activity, and intrinsic aerobic fitness
(University of Missouri--Columbia, 2013)
Insulin has important vascular and metabolic actions. The vascular effects of insulin typically account for as much as 40-50% of insulin-stimulated glucose disposal. However, the vascular reactivity to insulin is impaired ...
Targeting the myofibroblast : new strategies in managing equine corneal fibrosis
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Corneal disease is a common cause of blindness in horses as a result of various causes including traumatic, autoimmune, neoplastic, or infectious ...
Preclinical evaluation of 177Lu-BBR2 antagonist radiothearpy of prostate cancer
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Castration resistant prostate cancer (CRPC) is the second most common cause of cancer death in the United States. Current treatment protocols offer ...
Osteochondral allograft preservation in a serum-free chemically-defined media
(University of Missouri--Columbia, 2011)
Articular cartilage has a very limited capacity as compared to other biological tissues to repair and regenerate because of its avascular nature. Chronic degradation of articular cartilage may result in osteoarthritis, the ...
Hyperglycemia and type 2 diabetes : impact on neural cardiovascular control
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Alterations in blood pressure regulation are linked with increased risk for cardiovascular disease and mortality. Type 2 diabetes is often characterized ...
Noonan Syndrome with multiple lentigines : insights into hypertrophy and hypercontractility
(University of Missouri--Columbia, 2015)
Noonan Syndrome with Multiple Lentigines (NSML) is a rare genetic disease resulting in a phenotype with specific features, most importantly left ventricular cardiac hypertrophy. The majority of NSML cases result from ...
Cardiorespiratory fitness through the early lifecourse and attempts to modulate its initial decline
(University of Missouri--Columbia, 2015)
There has never been an outcome measure for human health more important than VO2peak, yet we know nothing about the molecular triggers for its decline with aging. Peak aerobic capacity (VO2peak) is a strong predictor of ...
Effects of voluntary running on brain mitochondrial biogenesis in rats selectively bred to run high and low nightly distances
(University of Missouri--Columbia, 2015)
It is known that brain mitochondrial dysfunction is strongly associated with the advent of neurodegenerative diseases and that exercise is an important non-pharmaceutical method of maintaining brain mitochondrial health. ...
The use of a lysostaphin fusion protein as a dry-cow treatment for chronic Staphylococcus aureua mastitis in dairy cattle
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] This study evaluated the efficacy of a lysostaphin-fusion protein (Lyso-PTD) as a dry-cow therapy for the treatment of experimentally-induced chronic, ...
Neurons projecting to the paraventricular nucleus of the hypothalamus are activated and contribute to cardiorespiratory responses to systemic acute hypoxia
(University of Missouri--Columbia, 2013)
Activation of peripheral and central chemoreceptors contributes to homeostatic responses that maintain optimal blood gas levels, including oxygen and carbon dioxide. Brainstem neurons in the nTS and CVLM integrate and ...
FAST kinase domain-containing protein 1 in mitochondrial function, cell death and cardiovascular disease
(University of Missouri--Columbia, 2016)
Cell death occurs during myriad circumstances and varied physiological and pathological conditions. Identifying novel modulators of cell death pathways is crucial to understanding and controlling cell death. Therefore, we ...
Role of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in upregulation of intermediate-conductance Ca[superscript 2+] -activated K[superscript +] channels (K[subscript Ca]3.1) associated with atherosclerosis
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] A key risk factor for the development of atherosclerosis is familial hypercholesterolemia (FH), a genetic disease characterized by elevated levels of ...
Metabolic responses to a westernized diet administered to rats selectively bred for high and low amounts of voluntary exercise
(University of Missouri--Columbia, 2015)
Introduction: The purpose of my study was to determine if rats with varying levels of inherent motivation to voluntarily run in wheels, when given no access to voluntary running wheels, would retain any protective affects ...
Physiological responses of adipose tissue to different models of physical activity and inactivity
(University of Missouri--Columbia, 2013)
Childhood is a critical time of growth, and decisions made during this time lead to positive and negative health consequences, specifically pertaining to adiposity. There is convincing evidence that children who are ...
The role and mechanisms of hexokinase-2-mediated protection against cardiac cell death and disease
(University of Missouri--Columbia, 2013)
Numerous cancer studies demonstrate that transformed cells exhibit both increased glucose metabolism and an increased propensity to survive in the face of stressful stimuli. These studies overwhelmingly correlate with ...
Hyperglycemia and type 2 diabetes : impact on neural cardiovascular control
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Type 2 diabetes (T2D) is often characterized by chronic hypertension and exaggerated increases in arterial blood pressure (BP) during exercise. However, ...