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On the pharmacological action of certain organic derivatives of arsenic with special reference to salvarsan and sodium cacodylate
(University of Missouri--Columbia, 1913)
Since the introduction of Salvarsan by Ehrlich in the latter part of 1910 many facts have been brought out concerning its reactions in the body. The most important of these pharmacologically are the deaths which have been ...
The determination of the lecithans in the tissues and fluids of the animal body
(University of Missouri--Columbia, 1905)
The Hoppe-Seyler method not offering a means of separation of the lecithins from the kephalins was not experimentally investigated. In attempting to apply the method of Koch to other tissues than the brain and spinal cord, ...
The absorption of fat by the mammalian stomach
(University of Missouri--Columbia, 1913)
A proper analysis of the function of the stomach in alimentation involves not only those factors which produce chemical and mechanical changes in the foods during its stay in the gastric cavity; but also, the extent to ...
The action of Digitalis on the cardiac inhibitory centre
(University of Missouri--Columbia, 1914)
So long has digitalis been in use as a clinical drug and so long has its action been the subject of experimentation that it would seem that there is little hope of presenting anything new on the subject. Yet so long as ...
The physiological significance of the anatomical changes produced in nerve cells by the action of certain bacterial toxins
(University of Missouri--Columbia, 1914)
During the last four years there has been a considerable amount of original investigation in this laboratory of the changes in nerve cells resulting from many forms of stimulation, both normal, and in the sense of being ...
The effect of digitalis on the cardiac peripheral neuro-muscular complex
(University of Missouri--Columbia, 1914)
The question of the action on the animal organism of the principles found in the leaves and flowers of Digitalis purpurea has long been one of absorbing interest. A glance at the long list of articles dealing with researches ...
The significance of the neurocytological changes following section of axones
(University of Missouri--Columbia, 1914)
There has been a considerable amount of work done on the effect of an interruption of the continuity of nerve axones. But most of the work was done from an anatomical or from a pathological instead of from a physiological ...
A study of the chemistry of nerve degeneration
(University of Missouri--Columbia, 1905)
It has been pointed out by a number of experimentors, that after section of a nerve, certain chemical changes are demonstrable. A notable example is the presence of fat, formed by degenerative processes and shown by Marchi's ...
The pharmacological action of certain bromide salts
(University of Missouri--Columbia, 1913)
The purpose of the work on which this paper is based has been to study the effects of some of the bromide salts upon the isolated heart of a frog as revealed by substituting the bromides of potassium, sodium, and calcium ...
Pharmacological action of acetanilide, antipyrine & acetphenetidin on cardiac muscle
(University of Missouri--Columbia, 1911)
It is a well-known fact that acetanilide and the antipyrine series, when administered in clinical cases, for antipyretic purposes, often have untoward and unexpected accompanying actions. These associated influences have ...
Pharmacological action of atropine on cardiac muscle
(University of Missouri--Columbia, 1911)
Does Atropine influence the cardiac rhythm and the power of the heart's contractions by direct action on its muscular tissue, and if so, to what extent and under what conditions? It is my purpose therefore in this work to ...
Mechanisms for chlorinated lipids in sepsis
(University of Missouri--Columbia, 2020)
Sepsis induces the formation of proinflammatory chlorinated lipids, stimulates adhesive interactions between the endothelium and leukocytes/platelets, causes mast cell activation, disrupts the microvascular barrier and ...
Functional recovery of the microcirculation during skeletal muscle regeneration
(University of Missouri--Columbia, 2018)
Skeletal muscle has a remarkable capacity to regenerate following injury, and although muscle regeneration has been studied extensively, little is known about the recovery of the skeletal muscle microcirculation during ...
Adenosine deaminase acting on RNA (ADAR1) in the development of abdominal aortic aneurysm and atherosclerosis
(University of Missouri--Columbia, 2021)
The main focus of this dissertation is the role of Adenosine deaminase acting on RNA (ADAR1) in the development of abdominal aortic aneurysm (AAA) and atherosclerosis. This first chapter of this document presents a review ...
Contribution of TRPV4 to enhanced calcium cycling and cardiac arrhythmia following ischemia-reperfusion in aged mouse hearts
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Cardiomyocyte Ca2+ homeostasis is altered with aging and predisposes the Aged heart to Ca2+ intolerance and arrhythmia. Transient Receptor ...
Dendritic cells contribute to perivascular adipose tissue dysfunction in type 2 diabetes
(University of Missouri--Columbia, 2017)
T2DM is a chronic disease characterized by low-grade inflammation in adipose tissue. Recent investigations have shown that a variety of immune cells can accumulate in adipose tissue contributing to the development of chronic ...
TRPV4 contributes to stretch-induced hypercontractility and time-dependent dysfunction in the aged heart
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Aims: Cardiovascular disease remains the greatest cause of mortality in Americans over 65. The stretch-activated Transient Receptor Potential Vanilloid-4 ...
Physiological and pharmacological characterization of the N1303K mutant CFTR
(University of Missouri--Columbia, 2018)
Background: N1303K, one of the common, severe disease-causing mutations in the CFTR gene, causes both defective biogenesis and gating abnormalities of the CFTR protein. The goals of the present study are to quantitatively ...
The fat and lipase content of the blood following fat feeding and during increased muscular work
(University of Missouri--Columbia, 1917)
Summary: 1. The fat content of the blood inoreases after a meal rich in cotton seed oil fat. 2. Cotton seed oil fat is more slowly digested than cream fat. 3. The lipase content of the blood increases after a meal of cotton ...
Cardiorespiratory abnormalities in early and advances stage mouse models of Duchenne muscular dystrophy
(University of Missouri--Columbia, 2021)
Duchenne muscular dystrophy (DMD) is an X-linked severe muscle disease caused by dystrophin gene mutations affecting 1 in 3,500 newborn males worldwide every year. DMD is characterized by progressive skeletal muscle ...