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Dendritic cells contribute to perivascular adipose tissue dysfunction in type 2 diabetes
(University of Missouri--Columbia, 2017)
T2DM is a chronic disease characterized by low-grade inflammation in adipose tissue. Recent investigations have shown that a variety of immune cells can accumulate in adipose tissue contributing to the development of chronic ...
CFTR gating mechanism: the role of dimerization of nucleotide binding domains
(University of Missouri--Columbia, 2009)
The chloride channel, cystic fibrosis transmembrane conductance regulator (CFTR) has two membrane spanning domains (MSD), forming the channel pore, and two nucleotide binding domains (NBD), controlling the channel gating ...