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Bivalent peptide-based radioconjugates for prostate cancer imaging and potential therapy
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Introduction: Despite decades of research, prostate cancer remains an important disease, with 1 out of 7 men diagnosed within his lifetime. In 2017, ...
Comprehensive profiling of micro RNA in human papillomavirus-associated squamous cell carcinoma of the head and neck
(University of Missouri--Columbia, 2014)
Evaluation of micro-dystrophin based and dystrophin-independent AAV gene therapies for Duchenne Muscular Dystrophy
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] Duchenne Muscular dystrophy (DMD) is the most common, progressive childhood muscular dystrophy with an X-linked inheritance. The major cause ...
Aberrant DNA methylationof RUN domain containing 3B in lymphoid malignancies
(University of Missouri--Columbia, 2013)
Heritable changes to DNA conformation can have significant impacts on gene expression without altering the DNA sequence. The RUN domain containing 3B gene (RUNDC3B) has been shown to be differentially expressed in cancer ...
Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Traumatic brain injury (TBI) is a highly prevalent cause of death and disability in the US and has become a significant burden to our present healthcare ...
3D analysis of hip joint mobility and the evolution of locomotor abilities in miocene hominoids
(University of Missouri--Columbia, 2013)
The emergence of extant ape-like locomotor behaviors has become a defining issue in reconstructing ape evolution. Suspensory positional behaviors, such as antipronograde bridging, climbing, clambering and transfer, distinguish ...
Computational modeling, ontogeny, and biomechanics of cranial forces in Alligator mississippiensis
(University of Missouri--Columbia, 2015)
3D computational modeling offers researchers tools to investigate forces in the skull during feeding and other behaviors. The American alligator and other crocodylians generate the highest bite forces among vertebrates, ...
Archosaur hip joint anatomy and its significance in body size and locomotor evolution
(University of Missouri--Columbia, 2015)
Archosaurs (crocodylians, birds and their extinct relatives) underwent numerous evolutionary transitions in limb morphology and body size, reflecting a diverse suite of postural and behavioral adaptations. Among archosaurs, ...
Development of post-traumatic osteoarthritis models to evaluate the effects of impact injury on joint health for clinical disease treatment and prevention
(University of Missouri--Columbia, 2013)
Osteoarthritis is one of the most common, debilitating, musculoskeletal diseases in the world. Currently, there is no cure. It is well-known that a traumatic, joint injury increases the risk of developing post-traumatic ...
Patients with venous thromboembolism have higher prevalence of obstructive sleep apnea than the general population
(University of Missouri--Columbia, 2010)
Study Objectives: Obstructive sleep apnea (OSA) has been linked to a large number of cardiovascular diseases. However, the link between OSA and venous thromboembolic events (VTE) remains unclear. We sought to study the ...
An anatomical analysis of the effects of ether anesthesia on the nerve cell
(University of Missouri--Columbia, 1915)
In this investigation the writer has attempted to ascertain whether or not the anatomical changes produced by ether are similar to those produced by morphine and heat stimulation, namely slight excitation followed by ...
Global DNA methylation and gene expression analysis in pre-B cell acute lymphoblastic leukemia
(University of Missouri--Columbia, 2015)
Acute lymphoblastic leukemia (ALL) is a hematological cancer associated with precursor B-cells and is the most common cancer diagnosed in children under the age of 15. Our complete understanding of all mechanisms responsible ...
Grasping pressures and phalangeal curvature in primates : an experimental in vivo approach
(University of Missouri--Columbia, 2015)
Phalangeal curvature is often used to infer arboreal locomotion in fossil primate species. This is based off an hypothesis of plasticity linked to a loading model that suggests that, when flexed during grasping, a curved ...
Dimorphism and integration in the pelves of anthropoid primates
(University of Missouri--Columbia, 2016)
The link between obstetric demand (natural selection for birth) and pelvic morphology in anthropoids has remained ambiguous for the past century. Though it is assumed that the dramatic sexual dimorphism seen in modern human ...
Interactions of parvoviruses with the cellular DNA damage response and CTCF
(University of Missouri--Columbia, 2021)
Nuclear DNA viruses must be able to simultaneously access cellular factors that aid their life cycle while evading inhibitory factors in order to sustain their expression and replication. Establishment of nuclear sites ...
Investigating age- and virulence factor- dependent innate immune activation during neonatal meningitis associated E. coli infection
(University of Missouri--Columbia, 2021)
Neonatal meningitis-associated Escherichia coli (NMEC) is a leading cause of early-onset sepsis and meningitis. While current antibiotic protocols have significantly reduced mortality associated with neonatal sepsis and ...
Interference with biologic transmission of Anaplasma marginale by targeting the tick-pathogen interface
(University of Missouri--Columbia, 2022)
Ticks are globally renowned vectors for numerous zoonoses. Ixodid ticks transmit a variety of viral, bacterial, and protozoan pathogens to their vertebrate hosts. Because of the expansion of the geographic ranges of both ...
Mechanisms of Alphavirus Midgut dissemination in the Mosquito, Aedes aegypti
(University of Missouri--Columbia, 2018)
The research work of this thesis has focused on the midgut escape barrier and the dissemination mechanism of alphaviruses in Ae. aegypti. Primarily, we identified and characterized Ae. aegypti MMPs that are seemingly ...
Temporal milestones during childhood : identification of a maturational spurt
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The transition of the human skeleton from immature to mature is characterized by a series of predictable milestones in both growth (e.g., peak height ...
Characterization of the rat Atg16l1 gene and its role in autophagy and disease
(University of Missouri--Columbia, 2020)
Crohn's disease (CD) is a potentially life-threatening inflammatory condition of the gastrointestinal tract affecting approximately 1.6 million Americans. Previous studies confirm the important role of genetics in IBD. ...