Search
Now showing items 1-20 of 24
On the role of IL-13R[alpha]1 on basophils, dendritic cells and macrophages in neonatal and adult immune systems modulation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] IL-13R[alpha]1 is a component of the heterodimeric receptor complex formed by IL-4R[alpha] and IL-13R[alpha]1. The receptor is mainly expressed on cells ...
Within and beyond immunomodulatory strategies against autoimmune diabetes : antigen-specific tolerance and endothelial regeneration
(University of Missouri--Columbia, 2013)
Type 1 diabetes (T1D) is a chronic disorder in which the cells of the immune system mediate selective destruction of the insulin-producing [beta]-cells in the islets of Langerhans in the pancreas. CD4+ effector T cells, ...
Yersinia pestis YopK contributes to immune evasion and cell death to promote plague
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] YopK is a 21-kilodalton protein that is secreted and translocated by the type three secretion system of Yersinia pestis, the causative agent of pneumonic, ...
Characterization of the non-structural proteins of adeno-associated virus (AAV) and minute virus of canine (MVC)
(University of Missouri--Columbia, 2012)
Parvoviruses are among the smallest of the animal DNA viruses. Due to their compact genome, these viruses display immense heterogeneity both in the mechanisms involved in gene expression and the functions of the encoded ...
Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity
(University of Missouri--Columbia, 2013)
Retroviral compatibility with diverse glycoproteins has been known and identified through the course of several studies. However, molecular mechanisms of glycoprotein acquisition are poorly defined. Glycoproteins are ...
The role of sphingosine kinase in influenza virus mediated inflammasome activitation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Influenza viruses continue to pose a grave burden on the global health and economy. Dysregulated innate immune system can lead to rapid infiltration ...
Mechanistic inhibition studies of SARS-CoV replication and entry
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Severe acute respiratory syndrome (SARS) is an infectious and highly contagious disease that is caused by SARS-associated coronavirus, (SARS-CoV) and ...
First contact :potential consequences of exposure of macrophage-like cells to divergent bacteria
(University of Missouri--Columbia, 2013)
The innate immune system must react to a wide variety of foreign stimuli, only a relatively small proportion of which may be classified as harmful. The goal of this thesis was to investigate interactions between macrophages ...
Factors contributing to humoral immunity against pneumonic plague
(University of Missouri--Columbia, 2012)
Yersinia pestis is the etiologic agent of plague and is responsible for more human deaths throughout history than any other bacterial pathogen. During infection bacteria inject effector proteins into target host cells using ...
Dendritic cells, IL-12Rbeta2, and IL-13Ralpha1 signaling: the battle for control of neonatal immunity
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Newborns are highly susceptible to microbial infections and allergic reactions. This susceptibility is due to a lack of Th1 cells and an excess of Th2 ...
Viral envelope proteins and the HIV-1 accessory gene Vpu mediate selectivity of viral and host proteins in retroviral assembly
(University of Missouri--Columbia, 2012)
Retroviruses are enveloped RNA viruses that assembly primarily at the plasma membrane of the host cell. During budding from the membrane, they acquire their own glycoproteins as well as a lipid bilayer derived from the ...
Amplifying peripheral tolerance in type 1 diabetes through regulatory T cells and inhibitory Fc receptors
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Type I Diabetes (TID) is a devastating autoimmune disorder in which autoreactive T cells attack the insulin-producing [beta] cells in the pancreatic ...
Dicer interacts with the P-granule component GLH-1 : both localize to C. elegans nuclear pores and to stress-induced oocyte RNP granules
(University of Missouri--Columbia, 2010)
P granules are ribonucleoprotein complexes specific to the cytoplasmic side of the nuclear pores of C. elegans germ cells. While P granules are implicated in post-transcriptional control of maternally-transcribed mRNAs, ...
Characterization of HIV-1 reverse transcriptase drug resistance connection subdomain mutation N348I
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Connection subdomain mutations are a recently discovered class of reverse transcriptase (RT) drug resistance mutations which are positioned at some ...
Piecing together the Plasmodium falciparum genome puzzle : characterization of genes/proteins, PFE0565w and PF11_0394
(University of Missouri--Columbia, 2011)
Malaria is still a significant problem around the world and, thus, better control methods are in great need. A key stage in the Plasmodium life cycle is the sporozoite because it exhibits dual infectivity in both the ...
Characterization of the role of the DNA damage response pathway in parvoviral replication
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] We report that low multiplicity infection with the autonomous parvovirus minute virus of mice (MVM) results in the activation of a DNA damage response ...
The RNA binding protein HuR : novel mouse models and T cell targets
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Posttranscriptional gene regulation is an important mechanism of controlling mRNA expression and protein production. The RNA binding protein has been ...
Identification and characterization of Bacillus anthracis spore-associated proteins
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Bacillus anthracis is a Gram-positive, rod-shaped, spore-forming bacterium and the etiological agent of anthrax. Spore formation is essential for ...
The roles of ERK pathway localization and the regulation of [beta]-catenin/Bcl-XL kinetic in thymic selection
(University of Missouri--Columbia, 2011)
Thymocytes undergo a process of development that serves to favor the differentiation of T-cells bearing self-MHC (major histo-compatibility complex) restricted T-cell receptors (TCR). Signaling through the TCR is crucial ...
Studies on the development of a bacillus endospore-based microparticle vaccine platform
(University of Missouri--Columbia, 2011)
The rapid and safe immunization of populations is critical in response to emerging infectious diseases or biological attacks. Currently, many subunit vaccines are insufficiently immunogenic to protect against pathogen ...