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Novel in vitro cell culture models for studying pharmacokinetic drug-drug interactions following oral administration
(University of Missouri--Kansas City, 2011-09-21)
In this study different in vitro models were developed to study the long term and short term drug- drug interactions occurring upon oral administration. MDCK cells were stably transfected for the simultaneous expression ...
Molecular assembly of polycyanoarenes with silver salts and synthesis of polycyclic aromatic hydrocarbonds
(University of Missouri--Kansas City, 2012)
This dissertation encompasses the investigation of two distinct subjects. In the first
part, which is in the area of molecular self-assembly, the complexation of organonitrile aryl
compounds with three different types ...
Light-activated biomacromolecules
(2013)
Biomacromolecules, mainly nucleic acids and proteins, are involved in
every cellular process and therefore their aberrant level or function is linked with
most of the diseases. Controlling these macromolecules using light ...
Development of Pentablock Copolymer Based Formulations for the Sustained Delivery of Protein Therapeutics in the Treatment of Posterior Segment Ocular Diseases
(2013)
We have successfully synthesized pentablock (PB) copolymers comprised of various FDA approved polymer blocks such as polyethylene glycol (PEG), polycaprolactone (PCL), polylactic acid (PLA) and polyglycolic acid (PGA). PB ...
Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
(2013)
Cidofovir (CDF) has shown potential in vitro and in vivo antiviral activity against cytomegalovirus (CMV) retinitis. However, low CDF permeability due to its hydrophilic nature limits its effectiveness. Furthermore, ...
Transporter-Targeted Prodrug Delivery to Improve Oral Bioavailability of Saquinavir
(2015-05-22)
Saquinavir (SQV) is the first antiretroviral protease inhibitor approved by Food and
Drug Administration in the United States for the treatment of HIV infection due to its
potent anti-HIV activity. However, some unfavorable ...
Total synthesis of (±)-cis-trikentrin B, (±)-herbindole A and (±)-herbindole B. investigation into the regioselectivity of 6,7-Indole aryne cycloadditions
(2013)
Total synthesis of benzannulated indole alkaloid natural products (±)-cis-trikentrin B,
(±)-herbindole A and (±)-herbindole B via intermolecular indole aryne cycloaddition are
described. The 5,6,7-tribromoindole was ...
Role of cytochrome P450 enzymes on alcohol/nicotine-mediated oxidative stress and cytotoxicity in monocytes/astrocytes: Implications for HIV-infected alcohol/tobacco users
(University of Missouri--Kansas City, 2012)
Alcohol abuse is known to induce liver diseases and neurodegeneration. Chronic alcohol use during medication is known to decrease drug efficacy and increase toxicity. In addition, alcohol is known to interact with other ...