Search
Now showing items 1-12 of 12
Molecular mechanisms of action for CFTR potentiators
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] As the culprit behind cystic fibrosis (CF) is the dysfunction of the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR), ...
Dendritic cells contribute to perivascular adipose tissue dysfunction in type 2 diabetes
(University of Missouri--Columbia, 2017)
T2DM is a chronic disease characterized by low-grade inflammation in adipose tissue. Recent investigations have shown that a variety of immune cells can accumulate in adipose tissue contributing to the development of chronic ...
TRPV4 contributes to stretch-induced hypercontractility and time-dependent dysfunction in the aged heart
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Aims: Cardiovascular disease remains the greatest cause of mortality in Americans over 65. The stretch-activated Transient Receptor Potential Vanilloid-4 ...
Physiological and pharmacological characterization of the N1303K mutant CFTR
(University of Missouri--Columbia, 2018)
Background: N1303K, one of the common, severe disease-causing mutations in the CFTR gene, causes both defective biogenesis and gating abnormalities of the CFTR protein. The goals of the present study are to quantitatively ...
Sodium-Glucose Cotransporter 2 Inhibitors regulate vascular cell function
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Vascular disease is the major cause of morbidity and mortality in diabetic patients. Although numerous factors contribute to the development of ...
Integrin adhesion response to chemical and mechanical stimulation
(University of Missouri--Columbia, 2017)
It is well recognized that arterial stiffness increases with aging and aging-related diseases, such as hypertension. The mechanisms for the increase in stiffness have been largely thought to be the result of changes in the ...
Mechanisms for chlorinated lipids in sepsis
(University of Missouri--Columbia, 2020)
Sepsis induces the formation of proinflammatory chlorinated lipids, stimulates adhesive interactions between the endothelium and leukocytes/platelets, causes mast cell activation, disrupts the microvascular barrier and ...
Contribution of TRPV4 to enhanced calcium cycling and cardiac arrhythmia following ischemia-reperfusion in aged mouse hearts
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Cardiomyocyte Ca2+ homeostasis is altered with aging and predisposes the Aged heart to Ca2+ intolerance and arrhythmia. Transient Receptor ...
Cardiorespiratory abnormalities in early and advances stage mouse models of Duchenne muscular dystrophy
(University of Missouri--Columbia, 2021)
Duchenne muscular dystrophy (DMD) is an X-linked severe muscle disease caused by dystrophin gene mutations affecting 1 in 3,500 newborn males worldwide every year. DMD is characterized by progressive skeletal muscle ...
Adenosine deaminase acting on RNA (ADAR1) in the development of abdominal aortic aneurysm and atherosclerosis
(University of Missouri--Columbia, 2021)
The main focus of this dissertation is the role of Adenosine deaminase acting on RNA (ADAR1) in the development of abdominal aortic aneurysm (AAA) and atherosclerosis. This first chapter of this document presents a review ...
Functional recovery of the microcirculation during skeletal muscle regeneration
(University of Missouri--Columbia, 2018)
Skeletal muscle has a remarkable capacity to regenerate following injury, and although muscle regeneration has been studied extensively, little is known about the recovery of the skeletal muscle microcirculation during ...
Molecular regulation of sarcomere function
(University of Missouri--Columbia, 2021)
Molecular regulation of striated muscle contraction is widely thought to be regulated through canonical thin filament mechanisms, i.e., Ca2+ activation of thin filaments. Dual filament regulation is a novel model of striated ...