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Mechanism of induction of vascular endothelial growth factor (vegf) in osteoarthritis
(University of Missouri--Columbia, 2006)
Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen and an angiogenic factor. Angiogenesis regulated by VEGF is a critical event in the pathogenesis of Osteoarthritis (OA). Over-expression of VEGF in ...
The role of load in initiation and progression of cartilage pathology
(University of Missouri--Columbia, 2007)
Articular cartilage is primarily responsible for dissipation of load in diarthrodial joints. Load plays a critical role in maintaining cartilage health, but can also be a primary contributing factor in cartilage disease ...
Effect of colostral administration practices on serum immunoglobulin concentration in dairy calves
(University of Missouri--Columbia, 2008)
Despite the accumulated understanding of the factors which affect passive transfer of colostral immunoglobulins and its recognized importance in dairy calves, approximately 35-40 % of US dairy calves have inadequate passive ...
Amino-terminal sequences of the bacillus anthracis exosporium proteins BCLA and BCLB important for localization and attachment to the spore surface
(University of Missouri--Columbia, 2008)
The exosporium is the outermost layer of the Bacillus anthracis spore. The predominant protein on the exosporium surface is BclA, a collagen-like glycoprotein. BclA is incorporated on the spore surface late in the B. ...
Spinal muscular atrophy and the therapeutic application of trans-splicing RNA
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Development of RNA modalities to re-direct pathogenic pre-mRNA splicing events is the key to curing monogenic diseases. Improving the efficiency of ...
The feasibility of interspecific rescue of endothelial/hematopoietic lineage deficiency
(University of Missouri--Columbia, 2012)
Here we propose to develop a mouse model which will establish “proof of principle” for future development of large animal (e.g. pig) models which could be used as actual human solid organ and blood donors as well as in ...
Development of model systems for the vector-host-pathogen interface of bubonic plague
(University of Missouri--Columbia, 2013)
Bubonic plague infections begin in the dermis when the pathogen is introduced by a flea during a routine blood feed. Several barriers separate Yersinia pestis from its replicative niche, including phagocytic cells in the ...
Biodistribution of lead, arsenic, and gold nanoparticles following respiratory, oral and IV exposure of rats and swine
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The presence of arsenic and lead in the environment above the naturally occurring levels can have detrimental health effects on people living in these ...
The evaluation of a bioactive biomaterial scaffold for the tissue engineering of articular cartilage
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bilayered tissue-engineered osteochondral (OC) grafts require the integration of two components; a superficial layer consisting of articular cartilage ...
Autologous bone marrow-derived mesenchymal stem cell transplantation as a therapy for neuronal ceroid lipofuscinosis
(University of Missouri--Columbia, 2007)
The Neuronal Ceroid Lipofuscinoses (NCLs) are a group of rare genetic diseases characterized by neurodegeneration and accumulation of autofluorescent lysosomal storage bodies in numerous cell types. There are currently no ...
Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis
(University of Missouri--Columbia, 2006)
Atherosclerosis is characterized by the narrowing of the arterial lumen due to formation of the plaque within the intimal layer of the arterial wall resulting in the impaired flow of blood to the target organs. Most severe ...
Characterization of the sporozoite and eythrocytic stages (SES) protein
(University of Missouri--Columbia, 2007)
The Plasmodium sporozoite is infective for mosquito salivary glands and vertebrate host tissues. Although it is a key developmental stage of the malaria parasite, relatively few sporozoite surface or secreted proteins have ...
The role of macrophages and anti-viral antibodies in West Nile virus pathogenesis
(University of Missouri--Columbia, 2006)
Since the introduction of West Nile virus into the United States in 1999, the virus has spread throughout the continental territory of the United States and it is suspected that the virus has moved present into Mexico and ...
Diagnosis, epidemiology and immunologic consequences of copper deficiency in calves
(University of Missouri--Columbia, 2006)
Copper is an essential micronutrient. Copper deficiency has been associated with disease states that decrease commercial beef production. Clinical manifestations of copper disease include anemia, diarrhea, long bone ...
Phylogenetic characterization of canine distemper viruses detected in naturally infected North American dogs
(University of Missouri--Columbia, 2006)
In 2004, dogs with clinical signs suggestive of viral disease known as canine distemper virus (CD) were referred to the University of Missouri Veterinary Diagnostic Laboratory for testing. From eleven such cases, a diagnosis ...
DLC1 as a comparative epigenetic biomarker for radiotherapy of Non-Hodgkin's lymphoma
(University of Missouri--Columbia, 2007)
The American Cancer Society estimates that 58,870 people were diagnosed with non-Hodgkin's lymphoma (NHL) in 2006, and 18,840 people died of the disease. Recent investigation of epigenetic gene regulation has identified ...
Characterization of interactions involving the polycystic kidney disease-causing proteins: SamCystin and Bicc1
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Rodent models, including the Han:SPRD-Cy rat and the jcpk mouse, have been useful for identifying and characterizing genes that cause Polycystic Kidney ...
Interaction of transcription factors in regulation of human chorionic gonadotropin (HCG) alpha subunit gene promoter activity
(University of Missouri--Columbia, 2009)
Chorionic Gonadotropin (CG), a glycoprotein hormone, is considered as a primary signal for maternal recognition of pregnancy in higher primates, including humans. CG is a heterodimer, consisting of an alpha subunit (CGA) ...
Use of the veterinary medical database to update the veterinary oncology literature
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In this dissertation we discuss the Veterinary Medical Database and how it can be used to perform epidemiological studies in the veterinary oncology ...
In vitro synovial fibrochondrogenesis for meniscal tissue engineering
(University of Missouri--Columbia, 2008)
A series of in vitro studies were performed to evaluate the fibrochondrogenic potential of synovial membrane cells, for the long term goal of inducing meniscal fibrocartilage healing and regeneration. The first study ...