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Selective modulation of estrogen receptors : 27-hydroxycholesterol is a negative allosteric modulator of er-beta activity and estradiol binding
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The estrogen receptors alpha (ER[alpha]) and beta (ER[beta]) are important regulators of development and growth in many major organ systems. In the ...
Characterization of 14-3-3 [chi] phosphorylation in phosphorus stress in Arabidopsis thaliana and investigation of acetyl-coA carboxylase regulation using quantitative mass spectrometry
(University of Missouri--Columbia, 2016)
Oilseed development involves coordination and regulation of a complex metabolic network for efficient production of storage compounds, including fatty acids, proteins, and carbohydrates. Recent advances in mass spectrometry ...
Bacterial ribosome conformational dynamics during translation termination and rescue
(University of Missouri--Columbia, 2017)
Hydrolysis of polypeptide from the ribosome is a critical step that must occur prior to the ribosome recycling phase of translation. Inability of cells to do so can result in translation inhibition and eventually leading ...
The musculoskeletal effect of exercise and soluble activin receptor type 2b in mouse models of osteogenesis imperfecta
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Osteogenesis Imperfecta (OI) is a heritable connective tissue disorder primarily due to mutations in the type I collagen containing tissues, such as ...
Making others happy : the best route to one's own happiness?
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] There are many positive psychology interventions whose aim is to help people improve their levels of happiness and well-being, some of which work ...
Structural studies of inhibition and resistance mechanism of EFDA, a human immunodeficiency virus reverse transcriptase inhibitor
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.]
Characterizing the roles of an Arabidopsis Epsin n-terminal homology domain protein in plant innate immunity
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The plasma membrane (PM) serves as a crucial point of contact between a plant cell and its environment. Localized at this critical interface are proteins ...
Investigating the role of arginine 21 in the structure and function of human [alpha]A-crystallin
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cataractogenesis in the eye lens occurs as a result of protein aggregation. Of the multiple mutations in [alpha]A-crystallins associated with the ...
Targeting estrogen- and hedgehog-signaling pathways in prostate cancer
(University of Missouri--Columbia, 2009)
Prostate cancer is the second most frequent cause of cancer deaths in men, and the risk to develop cancer increases with age. Since the lifespan of the society is progressively increasing, the importance of preventing the ...
A novel role for the ATP7A copper transporter in cancer
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is a trace metal with a ready capacity to gain or donate electrons. This property is harnessed by numerous enzymes to perform vital functions ...
Characterization of the effects of 3,3'-diindolylmethane (DIM) in the TRAMP mouse prostate cancer model and DIM's interaction with estrogen receptor signaling
(University of Missouri--Columbia, 2018)
3,3'- diindolylmethane (DIM) is an acid -derived compound formed during the digestion of indole-3-carbinol (I3C), which is one of the main compounds in cruciferous vegetables, such as broccoli, cabbage and kale. Studies ...
Dissecting water stress-induced molecular responses in the maize primary root
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Drought is an important environmental factor limiting crop growth and productivity. With additional pressures arising from population growth and global ...
Roles of clathrin-coated vesicle networks in plant immunity and development
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] For a plant cell, the plasma membrane (PM) is not only the interface with its environment but also a signaling platform. Proteins localized to the PM ...
The role of the P2X7 nucleotide receptor in salivary gland inflammation
(University of Missouri--Columbia, 2017)
Salivary gland inflammation is a hallmark of Sjogren's syndrome (SS), a common autoimmune disease characterized by lymphocytic infiltration and the consequent impairment of the salivary gland and loss of saliva secretion, ...
The influence of mRNA secondary structures on ribosome conformational dynamics
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Synthesizing proteins in the cell is a critical aspect of life. Protein synthesis is a complicated process and involve highly functional machines at a ...
Stability, states, and interactions of the enzyme PMM/PGM by NMR and multivariate analysis
(University of Missouri--Columbia, 2016)
Phosphomannomutase/phosphoglucomutase (PMM/PGM) contributes to the infectivity of an opportunistic human pathogen Pseudomonas aeruginosa by participating in carbohydrate biosynthesis. As a phospho-transfer enzyme, PMM/PGM ...
Protein components of the microbial mercury methylation pathway
(University of Missouri--Columbia, 2015)
Mercury (Hg) in the environment and the resulting methylmercury (CH3Hg+) produced by microorganisms has emerged as a global concern in the last 50 years after a series of high profile, large scale contamination events, ...
Interaction of secretory protein SecA with its binding partners : lipids and SecB
(University of Missouri--Columbia, 2016)
Thirty percent of proteins synthesized in the cytoplasm of E.coli are exported across or into the cytoplasmic membrane to reach their final destinations. The general secretory system exports precursor proteins through the ...
Study of PVCA and PVCB, two enzymes involved in making isonitrile-containing natural products in bacterial pathogens
(University of Missouri--Columbia, 2016)
Isonitriles, with an unusual functionality, are very versatile intermediates widely involved in organic synthesis. Interestingly, a variety of isonitriles were encountered in both marine and terrestrial systems as the ...
Advancing single molecule fluorescence microscopy through the study of dynamic macromolecules
(University of Missouri--Columbia, 2017)
We took a two pronged approach to our investigation of protein synthesis by the ribosome: 1) the generation of a novel fluorescence enhancing substrates 2) the development of a method for the generation of fluorescent ...