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The herpes simplex virus virion host shutoff protein is targeted to mRNA cleavage sites through interactions with components of the host translational apparatus
(University of Missouri--Kansas City, 2011-01-20)
of circularized RNA that normally experiences cap-dependent scanning and circularized RNA that initiates translation in a cap-independent manner. Results indicated that Vhs requires a free 5' end for specific cleavage of mRNA that undergoes cap-dependent scanning...