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The herpes simplex virus virion host shutoff protein is targeted to mRNA cleavage sites through interactions with components of the host translational apparatus
(University of Missouri--Kansas City, 2011-01-20)
of circularized RNA that normally experiences cap-dependent scanning and circularized RNA that initiates translation in a cap-independent manner. Results indicated that Vhs requires a free 5' end for specific cleavage of mRNA that undergoes cap-dependent scanning...
The Role of Host Translation Initiation Factors eIF4H and eIF4A and the Exon Junction Complex in the Control of mRNA turnover and Translation by the Virion Host Shut off Protein of Herpes Simplex Virus
During lytic infections, the HSV Vhs endonuclease (UL41) degrades many viral and cellular mRNAs. This endonuclease activity is dependent upon the ability of Vhs to bind the host translation initiation factors eIF4AI/II and eIF4H. eIF4AI and 4AII...
Regulation of Gene Expression by Non-coding RNAs in Arabidopsis and Brachypodium
Expansion of high-throughput sequencing technology has increased our understanding in the importance of pervasive transcription and the resulting indispensable molecules, noncoding RNAs (ncRNAs). A significant effort has ...
Structural and functional studies of type three secretion virulence factors from gram-negative pathogenic bacteria
(University of Missouri-Kansas City, 2011-12-21)
Many pathogenic Gram-negative bacteria utilize type III secretion systems (TTSS) to alter the normal functions of target host epithelial cells. Of the 1.1 million deaths that are caused by Shigella each year, nearly a third ...
Independent Functions Of Clueless In Differential Integrin Secretion And Mitochondrial Quality Control In Drosophila Muscle
Drosophila Clueless (Clu) and its conserved orthologs are known for their role in the prevention of mitochondrial clustering. Here, we uncover its independent roles in the delivery of integrin subunits and the regulation ...