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The Ins and Outs and ABCs of Antifungal Drug Transport: Characterizing the Role of Membrane Transporters in Pathogenic Fungi
(2016)
Pathogenic fungi cause serious disease and even death in humans, animals and plants. In medicine and agriculture alike, fungal infections are widespread and represent a significant threat to global public health. The number and array of fungal...
The Molecular Mechanisms of Antifungal Drug Resistance In Pathogenic Fungi
(2016)
Pathogenic fungi including Candida albicans, cause oral, systemic, and vaginal infections, mostly in immune-compromised individuals. Azoles are the most common antifungals used in treating these infections. The most ...
Regulation of Gene Expression by Non-coding RNAs in Arabidopsis and Brachypodium
(2014)
Expansion of high-throughput sequencing technology has increased our understanding
in the importance of pervasive transcription and the resulting indispensable molecules, noncoding
RNAs (ncRNAs). A significant effort has ...
Functional Sorting of Evolutionary Effects in Protein Domains
(University of Missouri--Kansas City, 2010)
One of the most important questions in evolutionary genetics is whether a gene of interest is under positive selection, negative selection or neutral evolution. Although there are numerous existed methods and statistical ...
Mating Type Specific Roles During The Sexual Cycle Of Phycomyces Blakesleeanus
(2014)
Phycomyces blakesleeanus is a filamentous fungus that belongs in the order Mucorales. It can propagate through both sexual and asexual reproduction. The asexual structures of Phycomyces called sporangiophores have served ...
Structural Basis for the Regulation of the Ceramide Transfer Protein
(University of Missouri -- Kansas City, 2017)
Ceramide, a central intermediate in sphingolipid metabolism, is synthesized at the
endoplasmic reticulum (ER) and transferred to the Golgi by the ceramide transfer (CERT)
protein for conversion to sphingomyelin (SM). ...