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Structural Basis for the Regulation of the Ceramide Transfer Protein
(University of Missouri -- Kansas City, 2017)
Ceramide, a central intermediate in sphingolipid metabolism, is synthesized at the endoplasmic reticulum (ER) and transferred to the Golgi by the ceramide transfer (CERT) protein for conversion to sphingomyelin (SM). ...
Effect of TIMBD on Neurotoxicity Associated with HIV-1 Gp120 and Tat
(University of Missouri -- Kansas City, 2018)
Human Immunodeficiency Virus (HIV)-associated neurocognitive disorder (HAND) is one of the undermining disorders that affects majority of HIV infected patients. Patients with HAND suffer from both cognitive and motor ...
Hyper-Plastic Structural Evolution Of The PEX Domain - A Model Of Evolutionary Exaptation And Neofunctionalization At The Molecular Level
(University of Missouri--Kansas City, 2017)
With the advent of sophisticated genetic, biophysical and in silico technology an enormous amount of information is being generated regarding the structural, biochemical and physiological aspects of proteins. Tertiary ...