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Molecular control of endothelial tube formation from single and aggregated cells by lumen signalling complexes that contain MT1-MMP and CDC42 in 3D collagen matrices
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The first blood vessels to form in the embryo are generated by vasculogenesis. New insight into vasculogenesis in mammals is emerging from studies of ...
Collecting lymphatic vessel permeability to albumin and its modification by natriuretic peptides
(University of Missouri--Columbia, 2010)
Microvascular exchange is the process whereby the blood provides the tissues of the body nutrients for cellular metabolism, macromolecules essential for fighting infection, and waste removal. However, these constituents ...
A role for insulin in the central control of sympathetic nerve activity in humans
(University of Missouri--Columbia, 2010)
Although well recognized for the regulation of peripheral metabolism, an emerging body of literature has begun to also establish a role for insulin in neural-cardiovascular control. In this regard, direct administration ...
Molecular mechanisms controlling endothelial cell-pericyte tube coassembly during vascular morphogenesis
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] From the onset the goal of this thesis work was to determine the role that a novel class of growth factors, i.e. hematopoietic cytokines, was playing ...
The control of blood flow in skeletal muscle arterioles
(University of Missouri--Columbia, 2010)
Skeletal muscle arterioles dilate in response to application of acetylcholine (ACh), eliciting a conducted vasodilation (CVD) that travels along unbranched segments without decrement. CVD is known to entail cell-to-cell ...
Functional and pharmacological importance of the composite ATP binding site 1 in CFTR chloride channels
(University of Missouri--Columbia, 2010)
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel whose defects cause the deadly genetic disease cystic fibrosis (CF). Like other ATP binding cassette (ABC) proteins, CFTR encompasses ...