Extensive reorganization of components of the genome is initiated in maize by the breakage-fusion-bridge (BFB) cycle. Displacements include chromosomes other than those undergoing the cycle. Restructuring ranges from those ...

The evidence on the compound structure of the R locus is reviewed. The more recent analysis of another group of R accessions, collectively known as R-cherry, seems to indicate that this locus is a gene cluster separable ...

The assumption that quantitative variation is produced by a large number of genes is re-examined. In fact, one finds that often only a small number of loci are involved. This, therefore, opens to careful study the developmental ...

Histone gene expression was studied during the cell cycle of continuously dividing HeLa S3 cells and after stimulation of confluent monolayers of WI-38 human diploid fibroblasts to proliferate. The presence of histone mRNA ...

Reproductive behavior in animals is modulated by an assortment of chemical signals. This paper focuses on substances that are externally emitted and are effective when a male and female are near or in contact with each ...

Specific mutants of Escherichia coli have been used in order to investigate certain aspects of ribosome function, bio synthesis and decay. These studies show that in the function of the ribosome its various components are ...

Mutagenic mechanisms can be divided into two categories, those dependent upon specific base mispairing (generating base pair substitutions and frameshift mutations) and those dependent upon misrepair (perhaps as a result ...

An effective fermentation organism is a wasteful creature that overproduces and excretes its metabolic intermediates and end products. Cultures obtained from screening programs usually possess subnormal regulatory controls. ...

The genetic diseases of man constitute a unique challenge to the medical scientist. For the past several years our laboratory has been developing new drugs for two of the more common genetic diseases - sickle cell anemia ...