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Novel inhibition mechanism and potent antiviral activity of translocation-deficient reverse transcriptase inhibitors [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Nucleoside RT inhibitors (NRTIs) are among the most potent anti-HIV agents and act as chain terminators because they lack a 3'OH. However, this feature can reduce affinity for RT compared to the analogous dNTP substrate, ...
Assessing the value of agricultural streams as amphibian refuges [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Although many causes for worldwide amphibian population declines are under investigation, the destruction and alteration of aquatic habitats remains a primary threat. In agricultural landscapes, natural wetlands are often ...
Carbon nanotubes and their composites with nanodiamond for thermal packaging: Syntheses, characterization and modeling [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
In the family of carbon-based nanosystems, carbon nanotubes (both single- and multi-walled) are cylindrical carbon molecules with many extremely useful properties that make them ideal for use in multitude of technological ...
Efficacy of a modified constraint induced movement therapy protocol in the clinical setting [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Constraint induced movement therapy (CIT) is an intervention strategy used by rehabilitation therapists for people who have experienced stroke. Traditional CIT protocols require participants to wear a restraint on their ...
Generating Gbx2 antibodies: A useful tool in determining developmental mechanisms regulated by GBX2 [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
The GBX class of homeobox genes is comprised of Gbx1 and Gbx2. Both loss-of-function and gain-of-function studies in mice have shown that Gbx2 is vital for normal anterior hindbrain development of mammalian organisms. To ...
Silencing of three members of the cytochrome p450 family of genes to uncover their role in iron regulation in A. thaliana
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
Iron absorption and distribution by an organism needs to be tightly regulated because iron is essential but in excess it can be dangerous and may even result in death. Through microarray analyses of iron-starved Arabidopsis ...
Processing brainwaves for hand-free control of devices [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
We have built a system to observe and analyze brainwaves for use in controlling devices such as wheelchairs and electronic prosthetics bypassing a need for the user to have use of their hands and/or other limbs. The system ...
Electric arc production of nanoparticles for energetic materials [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Thermites are a class of energetic material (similar to explosives) which consists of a fuel and oxidizer which react chemically to release energy. These materials are of interest because they can contain over 2.5 times ...
The role of gender in the peer review process of formal writing [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Traditionally, the assessment of student work has been the primary responsibility of a teacher or professor. However, the process of peer-review has truly taken hold in recent times as a method for others objectively ...
A multicopy suppressor screen in yeast to look for negative regulators of Ser13 phosphorylation-based trafficking to the pre-vacuolar compartment
(University of Missouri--Columbia. Office of Undergraduate Research, 2004)
Resident membrane proteins of the yeast trans-Golgi network (TGN) frequently cycle between the TGN and both the early and late (prevacuolar) endosomal compartments. The model yeast TGN protein, A-ALP, which contains the ...
Conversion of waste corncob to activated carbon for use of methane storage
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Missouri being one of the leading states in corn production has a large quantity of corn cobs. Corn cob can be used to produce activated carbon because its organic origin is similar to coconut and peach pits which have ...
Role of Cyclooxygenase-1 during the immunological response in lyme arthritis [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Previously, pharmacological inhibition of COX-1 in wild-type C3H mice resulted in changes in antibody production in response to infection with the causative agent of Lyme Disease, the spirochete Borrelia burgdorferi (Bb). ...
Roach colony optimization: a new approach to problem solving [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Computational intelligence, more specifically agent-based computing is a new way of thinking about computation that differs from the old methods of logical deconstruction and processing. We are developing a computational ...
Vegetation classification in urban nature areas in Columbia, Missouri [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Urban nature areas are often identified by local governments with no thought to their ecological characteristics or conservation value. We used a vegetation classification procedure, entitation, to classify vegetation types ...
Development of a RF Class E amplifier to power a ferroelectric plasma thruster [abstract]
(University of Missouri--Columbia. Office of Undergraduate Research, 2008)
Class E amplifiers are a special class of electronic amplifiers which are highly efficient at delivering power at high frequencies. Class E amplifiers consist of a signal generator, switch, and two LC resonant circuits. ...
Epithelial-mesenchymal transition of brain tumor cells is differentially regulated in response to dexamethasone
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
In the epithelial-mesenchymal transition of tumors, the loss of cohesivity and the migratory capability of cells determine the invasiveness and therefore the malignancy of the cancer. Understanding these biophysical ...
Optimization of metal-cyclization of alpha-MSH peptide analogs used in the treatment and detection of melanoma
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Over the past few years Dr. Quinn and his lab have made significant progress in the development of a melanoma treatment drug. Based upon peptide analogs of the alpha-melanocyte stimulating hormone, Α-MSH, Dr. Quinn has ...
Membrane permeability of Bovine Ooctyes to Propylene Glycol and the application to the improvement of Cryopreservation
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
In this study, the goal was to determine the permeability parameters of bovine oocytes for water (Lp) and Propylene Glycol (PPG) at temperatures of 30, 20, 10, and 5°C. By determining permeability parameters, we can model ...
The measurement of residual feed intake to determine feed efficiency of pregnant Hereford heifers
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
The large potential improvement in profitability is what makes feed efficiency such a studied and concerned topic in the beef industry today. Currently, no herd exists in the United States that has been selected solely for ...
Host-guest complexes to molecular encapsulation of hydrogen
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Science has always been about man learning from and attempting to mimic nature. In supramolecular chemistry this possibility is evident due to particularly interesting architectures of natural shell-like containers such ...