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Design and analysis of a new bounded log-linear regression model
(University of Missouri--Columbia, 2013)
This dissertation introduces a new regression model in which the response variable is bounded by two unknown parameters. A special case is a bounded alternative to the four parameter logistic model which is also called the ...
Two stage adaptive optimal design with applications to dose-finding clinical trials
(University of Missouri--Columbia, 2013)
In adaptive optimal designs, each stage uses an estimate of the locally optimal design derived using cumulative data from all prior stages. This dependency on prior stages a ffects the properties of maximum likelihood ...