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Silencing of the IKKepsilon gene by siRNA inhibits invasiveness and growth of breast cancer cells
(2010-09-23)
Abstract
Introduction
IκB kinase ε (IKKε) is a member of the IKK family that plays an important role in the activation of NF-κB. Overexpressed in more than 30% of breast cancers, IKKε has been ...
Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome
(2011-09-29)
Abstract
Background
Genome-wide association studies (GWAS) have identified new candidate genes for the occurrence of acute coronary syndrome (ACS), but possible effects of such genes on survival following ACS ...
Sex-dimorphic gene expression and ineffective dosage compensation of Z-linked genes in gastrulating chicken embryos
(2010-01-07)
Abstract
Background
Considerable progress has been made in our understanding of sex determination and dosage compensation mechanisms ...
Motivational Interviewing for encouraging quit attempts among unmotivated smokers: Study protocol of a randomized, controlled, efficacy trial.
(2012-06-19)
Abstract
Background
Although the current Clinical Practice Guideline recommend Motivational Interviewing for use with smokers not ready to quit, the strength of evidence for its use is rated ...
Perceptions of neighborhood social environment and drug dependence among incarcerated women and men: a cross-sectional analysis
(2012-09-10)
Abstract
Background
Perception of neighborhood social environment can influence an individual’s susceptibility to drug dependence. However, this has never been examined with a jailed ...
RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis
(2012-12-21)
Abstract
Background
Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. Growing evidence ...
Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data
(2011-01-25)
Abstract
Background
African Americans experience significant tobacco-related health disparities despite the fact that over half of African American smokers are light smokers (use ≤10 cigarettes per day). African ...
A Bayesian Analysis for Identifying DNA Copy Number Variations Using a Compound Poisson Process
(2010-08-17)
To study chromosomal aberrations that may lead to cancer formation or genetic diseases, the array-based Comparative Genomic Hybridization (aCGH) technique is often used for detecting DNA copy number variants (CNVs). Various ...
Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries.
(2011-04-14)
Abstract
Background
Dietary supplementation with tocotrienols has been shown to decrease the risk of coronary artery disease. Tocotrienols are plant-derived forms of vitamin E, which have potent anti-inflammatory, ...
Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage
(2010-10-05)
Abstract
Background
The ability to respond to changes in the extra-intracellular environment is prerequisite for cell survival. Cellular responses to the environment include elevating defense systems, such as the ...
Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.
(2010-12-16)
Abstract
Background
Inflammation has been implicated in cardiovascular disease, and the important role of proteasomes in the development of inflammation and other macrophage functions has been demonstrated. ...
Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.
(2010-12-16)
Abstract
Background
Inflammation has been implicated in cardiovascular disease, and the important role of proteasomes in the development of inflammation and other macrophage functions has been demonstrated. ...
delta-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens
(2011-02-28)
Abstract
Background
Chronic, low-grade inflammation provides a link between normal ageing and the pathogenesis of age-related diseases. A series of in vitro tests confirmed the strong anti-inflammatory activities ...
The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity
(2011-09-27)
Abstract
Background
The fungal pathogen Candida albicans is frequently seen in immune suppressed patients, and resistance to one of the most widely used antifungals, fluconazole (FLC), can evolve rapidly. In recent years ...
HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-kappaB pathway and can be silenced by gp120-specific siRNA
(2010-12-29)
Abstract
Background
The exact mechanism underlying HIV-associated neurocognitive disorders still remains largely unresolved. However, viral genes (for example gp120 and tat) and their effect on cytokine/chemokine ...
HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-kappaB pathway and can be silenced by gp120-specific siRNA
(2010-12-29)
Abstract
Background
The exact mechanism underlying HIV-associated neurocognitive disorders still remains largely unresolved. However, viral genes (for example gp120 and tat) and their effect on cytokine/chemokine ...
Insights into the pathogenesis of axial spondyloarthropathy from network and pathway analysis
(2012-07-16)
Abstract
Background
Complex chronic diseases are usually not caused by changes in a single causal gene but by an unbalanced regulating ...
Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor
(2012-06-14)
Abstract
Background: Altered immune function during ageing results in increased production of nitric oxide (NO) and other inflammatory mediators. Recently, we have reported that NO production was inhibited ...
Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes
(2012-03-15)
Abstract
Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous system toxicity of MA is well documented. The mechanisms contributing to this toxicity have not been fully elucidated. In this ...
A unified phylogeny-based nomenclature for histone variants
(2012-05-31)
AbstractHistone variants are non-allelic protein isoforms that play key roles in diversifying chromatin structure. The known number of such variants has greatly increased in recent years, but the lack of naming conventions ...