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Rapid detection and characterization of mycobacteria using microchannel electrical impedance spectroscopy
(University of Missouri--Columbia, 2017)
The presence of virulent, pathogenic bacteria in our body, food, water and other consumables is harmful and causes enormous economic and personal losses. Here we will be looking at developing a platform technology that can ...
Multi-frequency electrical impedance method for detection of viable micro-organisms, their quantification and their characterization
(University of Missouri--Columbia, 2013)
Despite advances in DNA based technologies and molecular methods, there are still several drawbacks to these methods and hence, there is a need for development of a new technology for microbial detection and quantification. ...
Rapid isolation of target bacteria from complex matrices
(University of Missouri--Columbia, 2010)
The long term goal of the research effort in our group was to develop a new rapid diagnostic process for sepsis. The specific project described in this work aims to obtain these "pure" isolates of the infectious bacteria ...
Microrna detection by surface plasmon resonance
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Lung cancer is the leading cause of cancer death in the world out of over 100 different known human cancers. Therefore there is a need for better ...
Direct from sample phenotypic antibiotic susceptibility testing
(University of Missouri--Columbia, 2018)
To transition from broad-spectrum antibiotic therapy to a more effective "targeted" therapy, i.e. in order to determine whether the infecting strain is resistant or susceptible to individual candidate antibiotics, clinicians ...
Direct-from-sputum rapid phenotypic drug susceptibility test for mycobacteria
(University of Missouri--Columbia, 2018)
The spread of multi-drug resistant tuberculosis (MDR-TB) is a leading global public-health challenge. Because not all biological-mechanisms of resistance are known, culture-based (phenotypic) drug-susceptibility testing ...
Rapid estimation of antibiotic efficacy of low bacterial inoculums using multi-frequency impedance measurements
(University of Missouri--Columbia, 2015)
Background: In order to obtain Minimum Inhibitory Concentrations (MICs), antibiotics are, by convention, tested against turbidometrically standard suspensions containing [about]5x105 CFU/ml of bacteria. This not only fails ...