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Fluorescent sensors for the detection of glucosamine and thiaminase
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Fluorescence chemical sensing is a highly important tool in science and industry with many applications in pharmaceutical screening, cell respiration, ...
Synthesis and photochemistry of PT (IV) hydroxo complexes
(University of Missouri--Columbia, 2015)
Global energy consumption and the production of clean renewable energy have become greater challenges. Sunlight-induced splitting of water into H2 and O2 is one of the leading strategies to achieve clean and renewable ...
Fluorine-18 capture by substituted BODIPY derivatives
(University of Missouri--Columbia, 2015)
For the medical community to effectively decrease the number of deaths caused by cancer each year, we must develop tools that allow for the early detection of biological abnormalities. Earlier detection is key to increasing ...
Characterization of acyclic rhodium tetrathioether ligans systems for 105Rh(III)
(University of Missouri--Columbia, 2015)
Rhodium-105 is a 36 hr half-life beta emitter potentially useful for radiotherapy. Previously, the reaction of 105 Rh-cholride with a linear tetrathioether ligand resulted in several species. Evaluation of this reaction ...
Spectroscopic distinguishability, forced degradation kinetics and lc-ms/ms degradation product characterizations involving 5-fluorouracil and similar or affiliated compounds in relation to environmental concerns
(University of Missouri--Columbia, 2015)
5-Fluorouracil (5-FU) is a commonly used antiviral and anticancer drug. 5-FU is believed to exist in various tautomeric forms, which are believed to contribute to 5-FU's cytotoxicity. In order to understand the activity ...
Strategies for the attachment of organic functional groups to silicon surfaces and measurement of vapor pressure of ionic liquids
(University of Missouri--Columbia, 2015)
Surface modifications of silicon surfaces have been studied for several decades. There are several approaches for attaching organic molecules with specific functionalities to these surfaces, utilizing both the selectivity ...
Development of cancer targeted Nampt inhibitors
(University of Missouri--Columbia, 2015)
The purpose of this research is the discovery of a highly potent pharmaceutical that can selectively cause apoptosis in various cancer cells. To utilize hydrophobic properties of carboranes, 1,7-dicarba-closo-dodecaborane ...
Development of advanced chemometric methods for analysis of deep-ultraviolet resonance Raman and circular dichroism spectroscopic data for protein secondary structure determination
(University of Missouri--Columbia, 2015)
Determination of protein secondary structure has become an area of great importance in biochemistry and biophysics as protein secondary structure is directly related to protein function and protein related diseases. While ...
Radiochemical and analytical methods of analysis of radiological dispersal devices
(University of Missouri--Columbia, 2015)
The events on September 11th 2001 and subsequent attacks in America and around the world have brought a renewed interest in the nation's security including the concern over the use of a nuclear or a radiological dispersal ...
Synthesis of exo-affinity labeling agents of protein tyrosine phosphatase non-receptor type 1
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Protein-tyrosine phosphatase 1B (PTP1B) is a negative regulator in the insulin signaling cascade. A lot of research has focused on inhibiting PTP1B ...
On the kinetics and mechanisms associated with covalent inactivation of protein tyrosine phosphatase 1b (ptp1b) by dietary phytochemicals and affinity labeling molecules
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Phytochemical are compounds that occur naturally in plants. These compounds are what give many foods their distinct color and flavor. There are five ...
Computational studies of five macromolecular systems
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] C-alkylpyrogallol[4]arenes have been studied by DFT computations and the results compared to experimental observations. Local minima of different ...
ICP-MS analysis of fission product diffusion in graphite for high-temperature gas-cooled reactors
(University of Missouri--Columbia, 2015)
High-temperature gas-cooled reactors (HTGRs) are one of the candidates being considered for the replacement of current nuclear reactor designs. Diffusion coefficients for fission products in HTGR graphite are required for ...
Structural and functional studies of proline catabolic enzymes and human aldehyde dehydrogenases
(University of Missouri--Columbia, 2015)
Oxidation of amino acids, like proline catabolism, is a central part of energy metabolism. Proline is oxidized to glutamate by two enzymes: proline dehydrogenase (PRODH) and 1-pyrroline-5-carboxylate dehydrogenase (P5CDH). ...
The effect of helix-breaking residues on Poly(LA)7
(University of Missouri--Columbia, 2015)
The purpose of this project is to study the effect of helix-breaking residues on a single pass transmembrane ?-helical peptide, Poly(LA)7 in aqueous and lipid environments. This was achieved by creating four substitutions ...
Radiolabeled bivalent peptide ligands for prostate cancer imaging
(University of Missouri--Columbia, 2015)
The diagnosis of prostate cancer in men in US continues to be a burden due to painfulness, non-specificity, and false positives of current methods. The usage of radiolabeled peptides as targeting vectors that selectively ...
Technetium from two perspectives : sulfide remediation and schiff base chemistry
(University of Missouri--Columbia, 2015)
Two major areas of focus in radiochemistry are environmental and pharmaceutical. This work looks at technetium-99 (Tc-99) chemistry from both viewpoints. The Manhattan Project led to millions of gallons of radioactive ...
Synthesis and reactivity of copper(i) amidinate complexes
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Group 11 transition metals are used daily throughout our bodies and as additives in many common products. One biological function of copper, a group ...
Arsenic for potential diagnostic imaging and radiotherapy
(University of Missouri--Columbia, 2015)
Targeted agents hold promise for non-invasive in vivo imaging, therapy, and monitoring of diseases. Foundational work focused on imaging and therapy of cancer has centered primarily on the use of 18F, 90Y, 99mTc, and 131I ...
A two-fold approach towards understanding properties of two self-assembled macrocycles: resorcin[4]arene and pyrogallol[4]arene
(University of Missouri--Columbia, 2015)
Self-assembled macrocycles, molecular entities that are connected together spontaneously in a cyclic manner, are studied herein. Pyrogallol[4]arene (PgC) and resorcin[4]arene (RsC), self-assembled macrocycles made from ...