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Evaluating the roles spinal plasticity and an accessory inspiratory muscle have in a rodent model of respiratory motor neuron death
(University of Missouri--Columbia, 2021)
Death by ventilatory failure most frequently occurs in patients with neuromuscular diseases in which there is a loss of respiratory motor neurons. There are currently no significant treatments to prolong or correct for ...
Mineralocorticoid receptor involvement in vascular dysfunction associated with vascular injury
(University of Missouri--Columbia, 2022)
Mineralocorticoid receptor (MR) signaling has recently been implicated in cardiovascular dysfunction associated vascular injury. Specifically, MR blockade has been shown to treat coronary microvascular dysfunction in obesity ...
The effects of heat stress and feed restriction on the microbiome of lactating dairy cows
(University of Missouri--Columbia, 2020)
Elevated environmental temperatures and relative humidity can cause heat stress in dairy cattle which results in decreased feed intake, reduced milk production, and increased disease incidence. Our objectives were to ...
The effect of gene therapy on the pathogenesis of amyotrophic lateral sclerosis (ALS)
(University of Missouri--Columbia, 2021)
Amyotrophic lateral sclerosis (ALS) is a devastating progressive and neurodegenerative disease. In early stages of ALS, there are known pathological changes in the structure of neuromuscular junctions (NMJ); however, all ...
The relationship between tooth extraction and changes in blood microbiome in horses
(University of Missouri--Columbia, 2021)
Bacteremia resulting from dental surgery is increasingly recognized as a health risk, especially in older and immunocompromised patients (in human medicine and also now in equine veterinary medicine). Dentistry-associated ...
The role of creatine supplementation and mTORC1 signaling in ameliorating cognitive deficiency in a neuroinflammatory rat model
(University of Missouri--Columbia, 2022)
Mild cognitive impairment (MCI) was defined as a boundary area between cognitive function of natural aging and dementia. Early studies have suggested that MCI could be a therapeutic window for prevention of dementia, given ...
Role of S100A9 in diabetic retinopathy
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Diabetic retinopathy (DR) is a microvasculature disease causing irreversible blindness in 50 [percent] of working adults with type 2 diabetes mellitus ...
Epigenetics of canine lung cancer development
(University of Missouri--Columbia, 2019)
Background: Human lung cancer is a leading cause of cancer related mortality and has significant economic impact. Cigarette smoking and exposure to second-hand smoke are a common cause of lung cancer development. Lung ...
The role of resistance exercise training & IGF-1 signaling in the amelioration of mild cognitive impairment in female Wistar rats
(University of Missouri--Columbia, 2021)
Mild cognitive impairment increases risk for dementia. One therapeutic intervention that is reported to ameliorate cognition in patients with mild cognitive impairment is resistance exercise. However, the underlying ...
Ventricle-specific fibrotic cardiac remodeling in the progression of heart failure with preserved ejection fraction
(University of Missouri--Columbia, 2022)
Heart failure with preserved ejection fraction (HFpEF) is currently the most prominent form of heart failure (HF). Despite the rising prevalence over the last few years, the pathogenesis of this disease is still unknown. ...
Mechanistic understanding and potential targets for mustard gas keratopathy
(University of Missouri--Columbia, 2022)
Sulfur mustard gas (SM), a vesicating and alkylating agent, has been used as a warfare agent since World War I and recently in Syria. SM exposure causes severe corneal injury, pain, and irreversible blindness. The cornea ...
Artificial neural network models utilize chamber-specific predictors of cardiac fibrosis in ovariectomized and aortic-banded Yucatan mini-swine
(University of Missouri--Columbia, 2022)
Objective: Heart failure with preserved ejection fraction (HFpEF) is a disease associated with significant clinical pathophysiological heterogeneity in which maladaptive cardiac fibrosis, in both the right and left ventricles ...
Phase I clinical trial evaluating calcium electroporation for management of cutaneous tumors in dogs
(University of Missouri--Columbia, 2023)
Traditionally, cutaneous tumors in dogs are managed with surgery, and adjuvant radiation therapy is considered in cases where complete resection is not achieved. Electrochemotherapy (ECT), with both cisplatin and bleomycin, ...