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Determining the differential roles of the dock family of GEFs in drosophila development
(2015-05-19)
The evolutionarily conserved Dock proteins function as unconventional guanine
nucleotide exchange factors (GEFs). Upon binding to ELMO (Engulfment and cell
motility) proteins, Dock-ELMO complexes activate the Rho family ...
Stereoisomeric Prodrugs to Improve Ocular And Oral Absorption of Prednisolone
(2015-08-11)
The primary objective of this project is to develop stereoisomeric prodrugs such as Lvaline-
D-valine-prednisolone (LDP) and D-valine-L-valine-prednisolone (DLP) to improve
ocular and oral absorption of prednisolone. ...
Independent Functions Of Clueless In Differential Integrin Secretion And Mitochondrial Quality Control In Drosophila Muscle
(2015)
Drosophila Clueless (Clu) and its conserved orthologs are known for their role in the prevention of mitochondrial clustering. Here, we uncover its independent roles in the delivery of integrin subunits and the regulation ...
Resveratrol Analogs: Potential Chemopreventive Agents in Breast Cancer
(2015-05-22)
Epidemiological data and studies in rodent models strongly support the role of
estrogens in the development of breast cancers. Estrogens have been added to the list of
known human carcinogens. Exact mechanisms underlying ...
The Roles of the Drosophila Protein Tribbles in Oogenesis and Insulin Signaling Pathway
(2015-06-02)
In this dissertation, I examined the molecular mechanism of function of the
Drosophila melanogaster protein Tribbles (Trbl) during oogenesis and larval
development. Trbl is the founding member of an evolutionarily conserved ...
Regulation of Antimicrobial Peptide Genes in the Tobacco Hornworm Manduca sexta
(2015-05-26)
The innate immune system, also known as natural or non-specific immune system, is conserved from insects to humans. The insect innate immune system is composed of humoral and cellular components. Insect humoral responses ...
Potential Mechanisms for Inhibition of Breast Cancer by Novel Azaresveratrol Analogs: Implications of Estrogen Receptor, Estrogen Metabolism and Cell Death Pathways
(2015-06-19)
Prolonged exposure to estrogens has been implicated in the development of breast cancers. Steroidal estrogens have been implicated in the initiation and progression of cancer. Estrogens bind to their cognate estrogen ...