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Identification of Novel Regulatory Genes in Acetaminophen Induced Hepatocyte Toxicity by a Genome-Wide CRISPR/Cas9 Screen
(University of Missouri -- Kansas City, 2018)
Acetaminophen (APAP) is a commonly used analgesic responsible for over 56,000
overdose-related emergency room visits annually. A long asymptomatic period and limited
treatment options result in a high rate of liver ...
Effect of TIMBD on Neurotoxicity Associated with HIV-1 Gp120 and Tat
(University of Missouri -- Kansas City, 2018)
Human Immunodeficiency Virus (HIV)-associated neurocognitive disorder (HAND)
is one of the undermining disorders that affects majority of HIV infected patients. Patients
with HAND suffer from both cognitive and motor ...
Structure/Function Analysis of Type IIa Receptor Tyrosine Phosphatases on Drosophila Muscle Integrity
(University of Missouri -- Kansas City, 2018)
The Lar-family of receptor protein tyrosine phosphatases (RPTPs); including
Lar, RPTPσ and RPTPδ, are utilized in signal transduction pathways during neural
development. Fundamentally, the processes of axon guidance ...
Mechanism of Action of Nicotinamide Phosphoribosyltransferase Mediated Signaling in Oxidative Stress
(University of Missouri -- Kansas City, 2018)
Worldwide there are an estimated 1 billion people that are affected by a form of
neurodegenerative disease. The most common forms of neurodegenerative disease are
Alzheimer’s disease and Parkinson’s disease, along ...