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APP∙CNTN Complex Architecture is Conserved Throughout the Vertebrate Lineage
(2020)
Contactins (CNTNs) are a group of up to six cell adhesion molecules (CAMs) of the immunoglobulin (Ig) superfamily found throughout the metazoan lineage. CNTN architecture is broadly conserved, and these proteins are composed ...
Non-genomic control of neuronal calcium signaling by the steroid hormone estrogen leads to neuroprotective effects
(2020)
It has been well documented that the onset of menopause correlates with an increase in the onset of neurodegenerative diseases such as Alzheimer’s disease. Estrogen supplementation was used as treatment/prevention for a ...
Investigation of functional domains of drosophilia tribbles protein in the insulin signaling pathway
(2020)
In this dissertation, I examined the function of the Drosophila melanogaster protein Tribbles (Trbl) within the insulin/insulin-like signaling (IIS) pathway. Trbl was initially discovered as a regulator of mitosis during ...
Structure-Function Analysis of the Tribbles Pseudokinase
(2020)
Members of the Tribbles (Trb) family of pseudokinases have roles in development, cell cycle control, insulin signaling, and the immune response and have been linked to many human diseases. The structure of Drosophila ...