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Polystyrene coated iron-platinum drug delivery platforms for theranostics
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cancer is the second leading cause of death in the United States, exceeded only by heart disease, and it is estimated that one in every four deaths is ...
Sustainable chemical approaches to two-dimensional nanosheets and mesoporous platforms and catalysts
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Green Chemistry, also called as Sustainable Chemistry, envisions minimum hazard to improve the efficiency and performance of materials while designing ...
Synthesis and properties of small molecules designed to covalently capture native and oxidized forms of protein tyrosine phosphatase 1B (PTP1B)
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Protein tyrosine phosphatase 1B (PTP1B) is a validated target for the treatment of type 2 diabetes and obesity. The discovery of selective inhibitors ...
Spectroscopic investigation of the effect of polyphenolic compounds on the amyloid-[beta] protein
(University of Missouri--Columbia, 2017)
Aggregation of the amyloid-[beta] (A[beta]) protein is associated with the development of Alzheimer's disease. A[beta] is a 39-43 residue cleavage product of the amyloid precursor protein (APP). A[beta] aggregates to produce ...
Synthesis and characterization of pn monoanionic ligands and their reactivity with actinides
(University of Missouri--Columbia, 2021)
Organoactinide complexes have gained much popularity in the recent decades particularly in the field of nuclear waste sequestration. With the increase of nuclear power along side other residual nuclear waste from power ...
Development of highly selective fluorescent sensors for detection of glycolipids in vesicles and visualization of glutamate for neuronal imaging
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] Fluorescent sensors are very useful tools for exploring chemical biology and advanced medical research. Herein, we propose four different ...
Spectroscopic investigations of the beta-amyloid peptide
(University of Missouri--Columbia, 2008)
The focus of this project is two-fold: examining the native structures of three different fragments of the beta-amyloid (A[beta]) peptide, and attempting to overcome some of the difficulties encountered in such an examination. ...
2,1-Benzothiazines : preparation and reactivity
(University of Missouri--Columbia, 2010)
The synthesis of chiral ligands to tune the reactivity and stereoselectivity of many catalytic asymmetric reactions has been given considerable attention in synthetic organic chemistry over the past decade. This report ...
Metabolically activated heterocyclic N-oxide compounds for killing and visualizing hypoxic cancer cells
(University of Missouri--Columbia, 2009)
Tirapazamine (TPZ) is currently undergoing a variety of phase I, II, and III clinical trials for the treatment of various human cancers. TPZ derives its medicinal activity by inducing DNA damage in poorly oxygenated tumor ...
Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m
(University of Missouri--Columbia, 2009)
The goal of this research is to cyclize octreotide analogues with ⁹⁹[supersript-m]Tc and ¹⁸⁶/¹⁸⁸Re radiometals to be used as diagnostic and therapeutic agents for neuroendocrine tumors, respectively. Several series of ...
Synthesis of mixed metal-organic pyrogallol[4]arene nanocapsules and their host-guest chemistry
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The formation of nanometer scale capsule (or capsule-like) assemblies continues to attract interest due to the potential application of such architectures ...
Development of advanced chemometric methods for the analysis of deep-UV resonance Raman spectra of proteins
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ultra violet resonance Raman (UVRR) is a powerful spectroscopic technique for determining the secondary structural content of proteins in solution. ...
Determination of trace elements levels in plasma from larvae in the course of baculoviral and bacterial infections by inductively coupled plasma-mass spectrometry (ICP-MS)
(University of Missouri--Columbia, 2009)
While a number of studies have examined the effect of infections on the trace elements status of mammals, not any similar study in insects are found. In this study, we used inductively coupled plasma-mass spectrometry ...
Studies of 2,1-benzothiazine, silver-catalyzed rearrangement and 1,5-hydride shift
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Dimethyl sulfoximine was used to synthesize benzothiazines by coupling reaction. When the substrate is dibromodibenzaldehyde, water was added to ...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Radiopharmaceuticals are drugs that contain a radioactive atom for the purpose of imaging or therapy of disease. The type of emission determines the ...
Development and application of inductively coupled plasma mass spectrometry techniques to investigate platinum chemotherapy agents
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cisplatin (cDDP), the first platinum chemotherapy compound, has been used in cancer chemotherapy in human beings and animals for more than thirty ...
Monte Carlo neutronic simulations for a new approach to parametric INAA and Mo-99 production feasibility at MURR
(University of Missouri--Columbia, 2009)
A novel approach to parametric instrumental neutron activation analysis at MURR has been established. In particular, a detailed MCNP5 steady-state model of the MURR core was developed. The model, which was based on the ...
Prospective radiolabled bombesin conjugates for prostate cancer imaging and therapeutic agents
(University of Missouri--Columbia, 2009)
An active area of prostate cancer research is in the synthesis of radiolabeled peptides for in vivo tumor imaging or therapy. This method is possible since specific receptors are expressed in high concentration on certain ...
Molecular organic solids for gas adsorption and solid-gas interaction
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] This following dissertation comprises three closely related sets of studies in order to explore the potential of molecular organic solids as a new ...
The synthesis and characterization of 1,1'-disubstituted ferrocene imine Schiff base ligand systems for use as potential environmental heavy metal cationic sensors
(University of Missouri--Columbia, 2008)
Heavy metals in the environment such as Cd, Hg and Pb are toxic to life forms. They can enter the ecological system through both natural and industrial sources. By developing chemical sensors that can detect these metals, ...