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Immunity in the newborn : control by IL-13 receptor and dendritic cells
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Neonates are susceptible to microbial infections and allergic reactions due to lack of Th1 immunity. Utilization of a TCR transgenic T cell transfer ...
T cells from immunological memory to autoimmune disease
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] T cells are one of the key components of the acquired immune response. These cells are instrumental in fighting bacterial and viral infections. ...
Immunotherapy for autoimmune diabetes
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Type I diabetes (TID) or insulin-dependent diabetes mellitus (IDDM) is an immunemediated disease in which the beta ([beta]) cells of the pancreatic ...
Two aspects of peripheral immune tolerance : systemic and mucosal tolerance mechanisms
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Autoimmune diseases are a significant cause of human morbidity and mortality. The defects in immune system that lead to the pathogenesis of autoimmune ...
Examination of neonatal immunity in IL-13 receptor alpha 1 deficient mice
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Recent work in our lab has demonstrated a role for interleukin-13 receptor alpha 1 (IL-13R[alpha]1) in the induction of apoptosis of T helper type 1 ...
Teaching T cells to remember : the role of antigen presenting cells in the development of CD4+ T cell memory
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Recent studies in our lab suggest that the number of divisions a naive T cell undergoes at the time of initial stimulation with antigen (Ag) affects ...
Amplifying peripheral tolerance in type 1 diabetes through regulatory T cells and inhibitory Fc receptors
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Type I Diabetes (TID) is a devastating autoimmune disorder in which autoreactive T cells attack the insulin-producing [beta] cells in the pancreatic ...
Within and beyond immunomodulatory strategies against autoimmune diabetes : antigen-specific tolerance and endothelial regeneration
(University of Missouri--Columbia, 2013)
Type 1 diabetes (T1D) is a chronic disorder in which the cells of the immune system mediate selective destruction of the insulin-producing [beta]-cells in the islets of Langerhans in the pancreas. CD4+ effector T cells, ...
Dendritic cells, IL-12Rbeta2, and IL-13Ralpha1 signaling: the battle for control of neonatal immunity
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Newborns are highly susceptible to microbial infections and allergic reactions. This susceptibility is due to a lack of Th1 cells and an excess of Th2 ...
On the role of IL-13R[alpha]1 on basophils, dendritic cells and macrophages in neonatal and adult immune systems modulation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] IL-13R[alpha]1 is a component of the heterodimeric receptor complex formed by IL-4R[alpha] and IL-13R[alpha]1. The receptor is mainly expressed on cells ...