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Characterization of the role of adenovirus-5 (Ad-5) gene products E2A, E4ORF6 and VA RNA on adeno-associated virus type 5 (AAV5) transcription, translation and replication
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] AAV5 is the most distinct serotype of the AAVs differing from the prototype virus AAV2 at the nucleotide level. We show that in AAV5 the Rep transcripts ...
T cells from immunological memory to autoimmune disease
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] T cells are one of the key components of the acquired immune response. These cells are instrumental in fighting bacterial and viral infections. ...
Serum resistance of an invasive nontypeable H. influenzae
(University of Missouri--Columbia, 2004)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Since the introduction of Haemophilus influenzae b polysaccharide-protein conjugate vaccines, the incidence of invasive H. influenzae disease dramatically ...
Immunity in the newborn : control by IL-13 receptor and dendritic cells
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Neonates are susceptible to microbial infections and allergic reactions due to lack of Th1 immunity. Utilization of a TCR transgenic T cell transfer ...
Rational design of split gene vectors to expand the packaging capacity of adeno-associated viral vectors
(University of Missouri--Columbia, 2007)
Adeno associated viruses (AAV) have recently been demonstrated as a very promising gene delivery vehicle. But the limited packaging capacity of AAV vectors (4̃.7kb) hinders their application for diseases involving large ...
Transcription regulation of adeno-associated viruses
(University of Missouri--Columbia, 2007)
The small genome size of adeno-associated viruses demand efficient gene regulation achieved by various strategies. This research compared these strategies from AAV2, AAV5 and bovine-AAV, and found that AAV2 capsid promoter ...
Effects of treprostinil sodium in a monocrotaline-induced rat model of pulmonary hypertension
(University of Missouri--Columbia, 2005)
Treprostinil is a prostacyclin analog currently used in the treatment of pulmonary hypertension. Although clinical studies show treprostinil to be a successful therapy for pulmonary hypertension, little information exists ...
Examination of specific amino acid residues of desulfovibrio desulfuricans cytochrome C₃ in electron transfer
(University of Missouri--Columbia, 2005)
Sulfate-reducing bacteria (SRB) are strictly anaerobic microorganisms present throughout the environment. These microorganisms are able to utilize a variety of electron donors and couple the oxidation of those compounds ...
Energy metabolism and uranium (VI) reduction by Desulfovibrio
(University of Missouri--Columbia, 2005)
Sulfate reducing bacteria (SRB) of the genus Desulfovibrio can breathe uranium in a manner similar to the way in which we (human beings) breathe oxygen. In respiration, we transfer electrons from food to oxygen, producing ...
Lipid mediators in the development and resolution of experimental lyme arthritis
(University of Missouri--Columbia, 2007)
The focus of my graduate studies was to determine the contribution of members of the eicosanoid cascade, namely the cyclooxygenase enzymes, to the regulation of experimental Lyme arthritis pathology. Using COX-2-specific ...
Characterization of cellular pathways in spinal muscular atrophy
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is an autosomal recessive genetic disease, and is the leading genetic cause of death in infants. SMA is a severe ...
Analysis of interactions between the germline RNA helicases (GLHs) and their regulators KGB-1 and CSN-5 in Caenorhabditis elegans
(University of Missouri--Columbia, 2006)
The Caenorhabditis elegans germline RNA helicases (GLHs) are constitutive components of P granules, non-membranous aggregates of protein and RNA that segregate with the nematode germline. The GLHs are critical for fertility. ...
Enterobactin export in escherichia coli via P43 (ents) and associated components
(University of Missouri--Columbia, 2006)
Ferric iron, critical for the metabolic functions of many microorganisms, is generally insoluble at neutral pH or quickly complexed by host iron storage proteins. To acquire necessary ferric iron against harsh competition ...
The innate immune response and toll-like receptors in the human endometrium
(University of Missouri--Columbia, 2005)
There are two major divisions of the human immune system: the adaptive and the innate immune systems. The adaptive immune responses are directed against specific pathogens and are essential for control and elimination of ...
Immunotherapy for autoimmune diabetes
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Type I diabetes (TID) or insulin-dependent diabetes mellitus (IDDM) is an immunemediated disease in which the beta ([beta]) cells of the pancreatic ...
Two aspects of peripheral immune tolerance : systemic and mucosal tolerance mechanisms
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Autoimmune diseases are a significant cause of human morbidity and mortality. The defects in immune system that lead to the pathogenesis of autoimmune ...
Stress response and hypothetical genes in Desulfovibrio vulgaris Hildenborough
(University of Missouri--Columbia, 2008)
The sulfate-reducing bacteria have a significant impact on the environment and the economy, necessitating further investigation of their physiology to harness their positive attributes and to minimize the damaging byproducts. ...
Alternative RNA processing and strategies to modulate splicing
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is a genetic disease that is intrinsically linked to an alternative RNA splicing event that leads a defective protein. ...
Regulating the regulators : using CD25 depletion to enhance immune responses to a model plasmid-based vaccine
(University of Missouri--Columbia, 2008)
Due to their ease of production and safety, plasmid-based vaccines have become prime candidates for both prophylactic and therapeutic human vaccination. In experimental animal models, vaccination with plasmid DNA expression ...
Functional characterization of two putative mobile elements of the 'Mycoplasma mycoides cluster'
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Horizontal gene transfer has played a major role in bacterial evolution, including in the genus Mycoplasma, which is comprised of some of the simplest ...