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Immunity in the newborn : control by IL-13 receptor and dendritic cells
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Neonates are susceptible to microbial infections and allergic reactions due to lack of Th1 immunity. Utilization of a TCR transgenic T cell transfer ...
Characterization of the role of adenovirus-5 (Ad-5) gene products E2A, E4ORF6 and VA RNA on adeno-associated virus type 5 (AAV5) transcription, translation and replication
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] AAV5 is the most distinct serotype of the AAVs differing from the prototype virus AAV2 at the nucleotide level. We show that in AAV5 the Rep transcripts ...
Hormonal regulation of innate immune responses and toll-like receptors in the human endometrium
(University of Missouri--Columbia, 2008)
This study examines the role of the steroid hormones, estrogen (E2) and progesterone (P4) in the regulation of TLR3-mediated mucosal immune responses in the human reproductive tract. TLR3 expression in endometrial epithelium ...
Regulating the regulators : using CD25 depletion to enhance immune responses to a model plasmid-based vaccine
(University of Missouri--Columbia, 2008)
Due to their ease of production and safety, plasmid-based vaccines have become prime candidates for both prophylactic and therapeutic human vaccination. In experimental animal models, vaccination with plasmid DNA expression ...
Alternative RNA processing and strategies to modulate splicing
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is a genetic disease that is intrinsically linked to an alternative RNA splicing event that leads a defective protein. ...
Piecing together the Plasmodium falciparum genome puzzle : characterization of genes/proteins, PFE0565w and PF11_0394
(University of Missouri--Columbia, 2011)
Malaria is still a significant problem around the world and, thus, better control methods are in great need. A key stage in the Plasmodium life cycle is the sporozoite because it exhibits dual infectivity in both the ...
Characterization of HIV-1 reverse transcriptase drug resistance connection subdomain mutation N348I
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Connection subdomain mutations are a recently discovered class of reverse transcriptase (RT) drug resistance mutations which are positioned at some ...
Role of Sds22 in the regulation of protein phosphatase-1 in Saccharomyces cerevisiae
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] GLC7 encodes the catalytic subunit of protein phosphatase 1 (PP1) in the budding yeast Saccharomyces cerevisiae. Glc7 binds different regulatory ...
Functional characterization of two putative mobile elements of the 'Mycoplasma mycoides cluster'
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Horizontal gene transfer has played a major role in bacterial evolution, including in the genus Mycoplasma, which is comprised of some of the simplest ...
Analysis of interactions between the germline RNA helicases (GLHs) and their regulators KGB-1 and CSN-5 in Caenorhabditis elegans
(University of Missouri--Columbia, 2006)
The Caenorhabditis elegans germline RNA helicases (GLHs) are constitutive components of P granules, non-membranous aggregates of protein and RNA that segregate with the nematode germline. The GLHs are critical for fertility. ...
Rational design of split gene vectors to expand the packaging capacity of adeno-associated viral vectors
(University of Missouri--Columbia, 2007)
Adeno associated viruses (AAV) have recently been demonstrated as a very promising gene delivery vehicle. But the limited packaging capacity of AAV vectors (4̃.7kb) hinders their application for diseases involving large ...
Transcription regulation of adeno-associated viruses
(University of Missouri--Columbia, 2007)
The small genome size of adeno-associated viruses demand efficient gene regulation achieved by various strategies. This research compared these strategies from AAV2, AAV5 and bovine-AAV, and found that AAV2 capsid promoter ...
Characterization of cellular pathways in spinal muscular atrophy
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is an autosomal recessive genetic disease, and is the leading genetic cause of death in infants. SMA is a severe ...
Serum resistance of an invasive nontypeable H. influenzae
(University of Missouri--Columbia, 2004)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Since the introduction of Haemophilus influenzae b polysaccharide-protein conjugate vaccines, the incidence of invasive H. influenzae disease dramatically ...
T cells from immunological memory to autoimmune disease
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] T cells are one of the key components of the acquired immune response. These cells are instrumental in fighting bacterial and viral infections. ...
Lipid mediators in the development and resolution of experimental lyme arthritis
(University of Missouri--Columbia, 2007)
The focus of my graduate studies was to determine the contribution of members of the eicosanoid cascade, namely the cyclooxygenase enzymes, to the regulation of experimental Lyme arthritis pathology. Using COX-2-specific ...
Energy metabolism and uranium (VI) reduction by Desulfovibrio
(University of Missouri--Columbia, 2005)
Sulfate reducing bacteria (SRB) of the genus Desulfovibrio can breathe uranium in a manner similar to the way in which we (human beings) breathe oxygen. In respiration, we transfer electrons from food to oxygen, producing ...
Immunotherapy for autoimmune diabetes
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Type I diabetes (TID) or insulin-dependent diabetes mellitus (IDDM) is an immunemediated disease in which the beta ([beta]) cells of the pancreatic ...
Two aspects of peripheral immune tolerance : systemic and mucosal tolerance mechanisms
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Autoimmune diseases are a significant cause of human morbidity and mortality. The defects in immune system that lead to the pathogenesis of autoimmune ...
Dicer interacts with the P-granule component GLH-1 : both localize to C. elegans nuclear pores and to stress-induced oocyte RNP granules
(University of Missouri--Columbia, 2010)
P granules are ribonucleoprotein complexes specific to the cytoplasmic side of the nuclear pores of C. elegans germ cells. While P granules are implicated in post-transcriptional control of maternally-transcribed mRNAs, ...