Search
Now showing items 1-4 of 4
Hyper-Plastic Structural Evolution Of The PEX Domain - A Model Of Evolutionary Exaptation And Neofunctionalization At The Molecular Level
(University of Missouri--Kansas City, 2017)
With the advent of sophisticated genetic, biophysical and in silico technology an
enormous amount of information is being generated regarding the structural, biochemical and
physiological aspects of proteins. Tertiary ...
Characterization of 5-methylcytosine dioxygenase Tet2 and rescue of mutant Tet2 activity by using turbo co-substrate
(2023)
Regulation of epigenetic transcription mediated by 5-methylcytosine (5mC) plays a critical role in eukaryotic development. Demethylation of these epigenetic marks is accomplished by sequential oxidation by ten-eleven ...
Functional Sorting of Evolutionary Effects in Protein Domains
(University of Missouri--Kansas City, 2010)
One of the most important questions in evolutionary genetics is whether a gene of interest is under positive selection, negative selection or neutral evolution. Although there are numerous existed methods and statistical ...
Calculating the structure-based phylogenetic relationship of distantly related homologous proteins utilizing maximum likelihood structural alignment combinatorics and a novel structural molecular clock hypothesis
(2013)
Dendrograms establish the evolutionary relationships and homology of species, proteins, or genes. Homology modeling, ligand binding, and pharmaceutical testing all depend upon the homology ascertained by dendrograms. ...