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Conformational Behavior and Structural Parameters of Some Cyclic and Chain Molecules
(University of Missouri--Kansas City, 2017)
The physicochemical properties of a molecule derive from its molecular structure, and
that structure often involves the orientation of one part of the molecule about a particular
bond with respect to the rest of the ...
Regulation of Antimicrobial Peptide Genes in Insects by the Toll Pathway and NF-kB Transcription Factors
(University of Missouri--Kansas City, 2017)
Insects lack adaptive immunity and solely rely on innate immunity to combat
pathogens. Innate immunity in dipteran and lepidopteran insects mainly depends on two
canonical pathways, the Toll pathway that provides ...
Structural Basis for the Regulation of the Ceramide Transfer Protein
(University of Missouri -- Kansas City, 2017)
Ceramide, a central intermediate in sphingolipid metabolism, is synthesized at the
endoplasmic reticulum (ER) and transferred to the Golgi by the ceramide transfer (CERT)
protein for conversion to sphingomyelin (SM). ...
Biochemical and Structural Studies of the Role of FKBP(L)s in the fly and Mammalian Circadian Cycle
(University of Missouri -- Kansas City, 2017)
FK506 binding-like proteins (FKBPLs) are proteins that structurally resemble the
immunophilins. Their functions in cell signaling include protein folding, molecular trafficking,
RNA splicing and cell cycle regulation ...
Hyper-Plastic Structural Evolution Of The PEX Domain - A Model Of Evolutionary Exaptation And Neofunctionalization At The Molecular Level
(University of Missouri--Kansas City, 2017)
With the advent of sophisticated genetic, biophysical and in silico technology an
enormous amount of information is being generated regarding the structural, biochemical and
physiological aspects of proteins. Tertiary ...
A Genetic Screen for Tribbles Suppressors Identifies the E3 Ubiquitin Ligase Neuralized as a Novel Target
(University of Missouri -- Kansas City, 2017)
In this dissertation, I used the Drosophila wing as a model tissue for a genetic screen
to identify novel targets of Tribbles. Drosophila Tribbles is the founding member of a family
of pseudokinases conserved between ...
Modulation of calcium signaling through direct and indirect actions of polyphenolic phytostilbenes on neuronal calcium channels
(University of Missouri--Kansas City, 2017)
Today in the United States there are 6.5 million people affected by a
neurodegenerative disease. Recent findings hypothesize that calcium dyshomeostasis and
reactive oxygen species contribute to the progression of many ...