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Protection from pneumonic plague by the induction of heme oxygenase-1
(University of Missouri--Columbia, 2018)
Yersinia pestis is the etiological agent of the disease known as plague. The pathology of this disease is characterized by organ failure due to necrosis and hyperinflammation towards the end of the disease. However, Y. ...
Contribution of the immune system and astrocytes to spinal muscular atrophy pathology
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease and the leading genetic cause of infant mortality. SMA is caused by ...
Regeneration of insulin-producing [beta]-cells during recovery from disease: a cure for Type 1 Diabetes
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Type 1 diabetes (T1D) is a chronic disease condition characterized by destruction of the insulin-producing [beta]-cells by self-reactive lymphocytes ...
Labeling HIV-1 nucleic acids during infection and effect of MOV10 in HBV replication
(University of Missouri--Columbia, 2018)
Technical limitations in simultaneous microscopic visualization of RNA, DNA, and proteins of HIV have curtailed progress in this field. To address this need we have developed a microscopy approach, multiplex immunofluorescent ...
Unraveling the role of the endogenous complex gut microbiota in the Pirc rat model of human colon cancer
(University of Missouri--Columbia, 2018)
The gut microbiota (GM) has recently been shown to modulate several systemic conditions in human and model systems, most importantly in intestinal disorders. It has also been demonstrated to have significant impacts on ...
Novel protective modifiers in mouse models of spinal muscular atrophy
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by the homozygous deletion or mutation in the survival motor neuron-1 (SMN1) gene ...
Duchenne muscular dystrophy gene therapy in the canine model
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Duchenne muscular dystrophy (DMD) is a devastating muscle wasting disease caused by loss of function mutations in the dystrophin gene, resulting in the ...
Mechanisms of immunity and inflammation in Brucella-induced arthritis
(University of Missouri--Columbia, 2018)
"Treatment of unresolved sterile arthritis such as rheumatoid arthritis or osteoarthritis involves eliminating or dampening host inflammatory responses. While inflammation may inflict severe articular pathology to the host ...
Mechanisms of clostridial toxin binding and translocation
(University of Missouri--Columbia, 2018)
The bacterial genus Clostridium consists of over 150 species of anaerobic, fermentative, spore-forming bacilli. Clostridial species produce up to 20% of all known bacterial exotoxins, which serve as important virulence ...