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A mouse model of embolic focal ischemic stroke for investigation of anti-thrombotic therapies
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Stroke is the third leading cause of death in the United States and the major cause of adult disability. Ischemic stroke accounts for about 87 percent ...
Stress, cognition and functional connectivity in the healthy human
(University of Missouri--Columbia, 2018)
Stress is known to negatively impact physiological and psychological processes in humans. While chronic exposure to stress has been implicated in the pathology of numerous physiological and neuropsychological disorders, ...
Associations between psychophysiological, immune, endocrine, and serotonergic biomarkers of stress and gastrointestinal symptoms in autism spectrum disorder
(University of Missouri--Columbia, 2016)
Autism spectrum disorder (ASD) is often accompanied by gastrointestinal (GI) disturbances, which also may impact behavior. Alterations in autonomic, endocrine, and immune system functioning are also frequently observed in ...
Dietary inflammatory index in patients with Alzheimer's dementia compared to controls
(University of Missouri--Columbia, 2018)
Alzheimer's dementia (AD) is a chronic neurodegenerative disease causing progressive memory loss, cognitive decline across numerous domains, and, eventually, loss of daily living activities. Mild cognitive impairment (MCI) ...
The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
(University of Missouri--Columbia, 2016)
Oxidative and nitrosative stress is known to play an important role in neurodegenerative and neuroinflammatory diseases, such as Alzheimer's disease, Parkinson's disease, ischemic[slash]hemorrhagic stroke, and traumatic ...
Network coherence in autism spectrum disorder : a multimodal neuroimaging study of functional connectivity and spectroscopy MRI
(University of Missouri--Columbia, 2015)
The underlying neuropathology and effects on neuronal activity in individuals with ASD are still being elucidated; as well as their impact on intervention and treatment outcomes. Frontal, temporal, parietal and cerebellar ...
The role of docosahexaenoic acid in stress reprogramming and behavior
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The role of DHA (Docosahexaenoic acid [22:6(n-3)]) is known to play an important role in complex behaviors such as learning and memory, anxiety and ...
The role of the amygdala in palatability and homeostatic models of high-fat feeding
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Previous research has demonstrated a dissociation of certain neural mediators that contribute to the increased consumption of a high-fat diet following ...
CNS effects of blood-borne relaxin on the paraventricular nucleus of the hypothalamus
(University of Missouri--Columbia, 2013)
Pregnancy is characterized by increased blood volume and baseline sympathetic nerve activity, and profound cardiovascular adaptations. Relaxin (RLX), an ovarian hormone which is elevated in pregnancy, activates the subfomical ...
Interaction between seratonin transporter genotype and prenatal stress on neurodevelopment with implications for autism spectrum disorder
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Prenatal stress has been shown to have a profound and lasting impact on brain development. Stress exposure during pregnancy has been implicated in ...
The effect of maternal genotype, prenatal stress, and perinatal diet in offspring behavior in an animal model of autism
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] While the etiology of autism spectrum disorders is unknown, it is thought that a combination of genetic and environmental factors contribute to the ...
Effects of beta-adrenergic antagonism in autism spectrum disorder
(University of Missouri--Columbia, 2016)
Effective treatments for individuals with autism spectrum disorder are lacking, especially when it comes to pharmacological intervention, which can be an important addition to behavioral therapy. Currently available agents ...
Matrix metalloproteinase-9 : surrogate marker and therapeutic target against neurovascular impairment after cerebral ischemia
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Stroke ranks fourth among all causes of death, and acute ischemic stroke is the most common form. The neurovascular unit (NVU) describes a basic ...
Canine degenerative myelopathy : perspectives from aging, microglia and neurofilaments
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Canine degenerative myelopathy (DM) is a late-onset neurodegenerative disease similar to some forms of amyotrophic lateral sclerosis (ALS). Mutations ...
Examination of biological factors that mediate the influence of physical activity on palatability driven feeding
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Palatability driven feeding- consuming food for pleasure, and voluntary physical activity are mediated by and influence similar neural mechanisms. ...
Low-intensity blast-induced mild traumatic brain injury : linking blast physics to biological outcomes
(University of Missouri--Columbia, 2019)
Blast-induced mild traumatic brain injury (mTBI) is of particular concern among military personnel due to exposure to blast energy during military training and combat. The impact of primary low-intensity blast (LIB) mediated ...