Search
Now showing items 1-11 of 11
Evaluation of siRNA mediated Silencing of IKKα in Prostate cancer and CD40 in Type-1 Diabetes
(2014-09-30)
The objective of this dissertation is to present the various therapeutic approaches for two distinctly different diseases, prostate cancer and type-1 diabetes. Our objective (1) for prostate cancer is to evaluate the siRNA ...
Evaluation of therapeutic effect of PCBP2 siRNA on hepatic stellate cells and development of a streptavidin-based siRNA delivery system
(2014)
Type I collagen accumulates during liver fibrosis primarily because α-complex protein-2 (αCP2), encoded by the poly(rC) binding protein 2 (PCBP2) gene, binds to the 3′end of the collagen mRNA and increases its half-life. ...
Discovery of PSMA-Specific Peptide Ligands and Development of A Noncovalent Method to Attach Chemical Moieties to siRNA
(University of Missouri -- Kansas City, 2017)
The objective of this dissertation is to discover PSMA (Prostate Specific Membrane
Antigen)-specific peptide ligands using phage display and employ peptide nucleic acid as
a complementary linker to attach chemical ...
Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
(University of Missouri--Kansas City, 2016)
The objective of this dissertation is to present two approaches to identify Hepatic
Stellate Cells (HSCs) targeting ligands using phage-display library biopanning and
systematic evolution of ligands by exponential ...
Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
(University of Missouri -- Kansas City, 2018)
The objective of this dissertation is to develop various systems to deliver small
interfering RNA (siRNA) for the treatment of triple negative breast cancer (TNBC) and
liver fibrosis. siRNAs targeting vascular endothelial ...
Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
(University of Missouri -- Kansas City, 2018)
Prostate cancer is the most common male malignancy and remains the second-leading
cause of death due to cancer in American men. While surgery and radiation are effective in
prostate cancer therapy at early stages, the ...
Development of Protein Based PCBP2 siRNA Nanocomplex for Liver Fibrosis Therapy
(University of Missouri -- Kansas City, 2018)
The objective of this dissertation is to develop a protein-based siRNA
nanocomplex for the treatment of alcoholic liver fibrosis. Our laboratory recently
discovered that silencing the poly (rC) binding protein 2 (PCBP2) ...
Development of Amino Acid-Modified Drug Delivery Systems for RNA Delivery in Cancer Therapeutics
(2022)
The primary objective of my research is to develop polymer and lipid-based nanoparticles to effectively deliver therapeutic RNAs for life-threatening diseases. Small interfering RNAs (siRNAs) and messenger RNAs (mRNAs) are ...
Discovery and Delivery of Peptide-Based Immune Checkpoint Inhibitors Targeting Pd-L1 for Cancer Immunotherapy
(2022)
The objective of this dissertation is to develop peptide-based immune checkpoint inhibitors that block the interaction between programmed cell death ligand-1 (PD-L1) and its receptor programmed cell death protein 1 (PD-1) ...
Evaluation of the Anti-Fibrotic Activity of PCBP2 siRNA in Primary Hepatic Stellate Cells and Discovery of Anti-PD-L1 Peptide and Nanobody for Immunotherapy
(University of Missouri -- Kansas City, 2018)
There are two major research objectives in this dissertation. Our laboratory
recently discovered a small interfering RNA (siRNA) that silences the poly (rC) binding
protein 2 (PCBP2) gene. It is hypothesized that silencing ...
Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
(2022)
In the last few decades cancer immunotherapy has emerged as a standard pillar of cancer treatment. Immune checkpoint inhibitors that are currently available target the adaptive immune system, generating T-cell antitumor ...