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Microenvironmental regulation of ovarian cancer dissemination via activation of the Wnt signaling pathway
(University of Missouri--Columbia, 2012)
Disseminating single cells and multicellular aggregates (MCAs) and experience compressive forces exerted upon them by ascites fluid and are exposed to lysophosphatidic acid, aberrantly adhesive mesothelium and a collagen-rich ...
Membrane type 1 matrix metalloproteinase proteolytic activity in initial adhesive and invasive events of ovarian cancer metastasis
(University of Missouri--Columbia, 2014)
Epithelial ovarian cancer (EOC) is one of the most common gynecologic malignancies, generally developing in women over the age of forty. When EOC are diagnosed prior to metastatic dissemination, the overall 5-year survival ...