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Investigation of the kinetcis [sic] and mechanisms of the inactivation of PTP-SHP2 peroxycarbonate and phytochemicals
(University of Missouri--Columbia, 2012)
Protein tyrosine phosphatases (PTPs) have a catalytic cysteine in their active site, and have a phosphor-enzyme intermediate. PTPs work in tandem with protein kinases in order to regulate many cellular signaling pathways. ...
Determination of trace elements levels in human plasma and radiated mice tongue by inductively coupled plasma-mass-spectrometry (ICP-MS)
(University of Missouri--Columbia, 2012)
An analytical method that uses a minimum150 μL of human plasma samples for the trace elements Fe, Cu, Zn, Mg and ultratrace elements Mn, Co, Cd, Pb was developed. The method was evaluated using both high resolution sector ...
Tan A : a fluorogenic probe for thiaminase I activity
(University of Missouri--Columbia, 2012)
Vitamin B1 plays important role in cell metabolism. Deficiency of vitamin B1 can cause ailments in living organism, including EMS (Early Mortality Syndrom) in the predatory fish salmon in the Great Lakes. Deficiency of ...
11-amino-1 undecene-covered SI (100) and GE (100) surfaces
(University of Missouri--Columbia, 2012)
Due to the similar properties and structures of silicon and germanium surfaces, they have similar methods of passivation and organic functionalizaiton reactions. The formation of organic monolayers on semiconductor surfaces ...
Bioreductive metabolism of small molecule nitroaromatics and N-oxides in hypoxia
(University of Missouri--Columbia, 2012)
Hypoxia in tumors causes adverse effects to therapy and negatively impacts on patient prognosis. Identification and quantification of hypoxia is considered to have a strong impact on treatments in tumor therapy. Fluorescent-based ...
Bioreductive metabolism of small molecule nitroaromatics and N-oxides in hypoxia
(University of Missouri--Columbia, 2012)
Hypoxia in tumors causes adverse effects to therapy and negatively impacts on patient prognosis. Identification and quantification of hypoxia is considered to have a strong impact on treatments in tumor therapy. Fluorescent-based ...
Conformational studies on adenine formation and spin properties of bio-related radicals
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] This dissertation summarizes a few different projects I have contributed to in Dr. Glaser's group during the past five years. The first part is chapter ...
Deep ultraviolet resonance Raman spectroscopy of membrane proteins
(University of Missouri--Columbia, 2012)
Despite the various protein structure determination methods in use, a need still exists for adequate resolution of membrane protein structure while remaining rapid and inexpensive. Deep-UV resonance Raman (DUVRR) spectroscopy ...
1,5-hydride shift of alkenyl sulfoximine/[4+3] cycloaddition and ring opening/novel hydrazine synthesis from Tröger's base analogues
(University of Missouri--Columbia, 2012)
Three synthetic methodologies are studied in details in this dissertation. For 1,5-hydride shift of alkenyl sulfoximine methodology, the reaction mechanism was studied using deuterium labeling. An uncommon 6-endo-trig ...
Structural diversity of proline catabolic enzymes revealed by small angle x-ray scattering, x-ray crystallography and light scattering
(University of Missouri--Columbia, 2012)
The proline catabolic enzymes catalyze the 4-electron oxidation of proline to glutamate. The reaction involves two enzymes, proline dehydrogenase (PRODH) and Δ1-pyrroline -5-carboxylate dehydrogenase (P5CDH). Some bacterial ...
Fluorescent sensors for lipids and hydrophobic amines in aqueous solution
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] A series of novel fluorescent sensors were designed and synthesized to detect lipids and hydrophobic amines in aqueous solutions. The closed allyl ...
Measurement of fatty acids in toenail clippings using GC-MS
(University of Missouri--Columbia, 2012)
Omega-3 fatty acids play an important role in human health and nutrition. Here, we investigated human toenail clippings as a potential, non-invasive and cumulative biomonitor for fatty acids, and successfully developed a ...
Sythesis, characterization and reactivity of platinum (II) peroxo, alkoxide and triflate compunds
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The chemistry of a collection of platinum(II) compounds, including peroxo, alkoxide and triflate compounds, were synthesized and studied. This involved ...
Synthesis, characterisation photophysical and DFT studies of 2,2'-diphenylenegold(III) diethyldithiocarbamate
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cyclometalated gold(III) complexes have been demonstrated to show electroluminescence properties and have been employed as electrophosphorescent ...
Intrinsic dosimetry : properties and mechanisms of thermoluminescence in commercial borosilicate glass
(University of Missouri--Columbia, 2012)
Intrinsic dosimetry is the method of measuring total absorbed dose received by the walls of a container holding radioactive material. By considering the total absorbed dose received by a container in tandem with the physical ...