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Functional and pharmacological importance of the composite ATP binding site 1 in CFTR chloride channels
(University of Missouri--Columbia, 2010)
The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel whose defects cause the deadly genetic disease cystic fibrosis (CF). Like other ATP binding cassette (ABC) proteins, CFTR encompasses ...
Molecular physiology and pharmacology of the CFTR chloride channel
(University of Missouri--Columbia, 2012)
Cystic fibrosis transmembrane conductance regulator (CFTR) is the only ATP binding cassette (ABC) protein that functions as an ion channel. The clinical importance of CFTR lies in the fact that its malfunction causes the ...