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Optimization of metal-cyclization of alpha-MSH peptide analogs used in the treatment and detection of melanoma
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Over the past few years Dr. Quinn and his lab have made significant progress in the development of a melanoma treatment drug. Based upon peptide analogs of the alpha-melanocyte stimulating hormone, Α-MSH, Dr. Quinn has ...
Conversion of waste corncob to activated carbon for use of methane storage
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Missouri being one of the leading states in corn production has a large quantity of corn cobs. Corn cob can be used to produce activated carbon because its organic origin is similar to coconut and peach pits which have ...
Construction of a knockout targeting vector to generate an Interleukin-13 Receptor α1 deficient Balb/c mouse
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
A recent publication from our lab has provided evidence for the involvement of the α1 chain of the Interleukin-13 cytokine receptor (IL-13Rα1) in the development of the neonatal immune system. Specifically, we have shown ...
Landscape design for Bear Creek Prairie in Columbia, Missouri
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Bear Creek Prairie is a proposed conservation development in Columbia, Missouri whose vision statement is “to develop a residential community that is environmentally responsible, pedestrian friendly, encourages community ...
Desiccation rates of Rana sylvatica, Rana clamitans, and Bufo americanus in a fragmented forest
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Habitat loss and fragmentation are the primary causes in the declines of amphibian populations. Farming, urban sprawl, and logging have created a mosaic of developed and undeveloped land that may create barriers between ...
Functional analysis of MAP kinases in Arabidopsis thaliana: Fully rescuing the mpk3/mpk6 mutant phenotypes
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Mitogen Activated Protein Kinase (MAPK) cascades are three-stage modules involved in signal transduction. MAPKs function at the lower tier of these cascades and they phosphorylate transcription factors and other protein ...
Binding properties of X29 protein and RNA
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
The Peculis Lab previously demonstrated that X29 protein binds U8 snoRNA with high affinity and specificity in Xenopus Laevis [1]. U8 snoRNA is a C/D box RNP required for pre-rRNA maturation of 5.8s and 28s rRNA in the ...
A century later another surprise: A non-visual behavioral function of the white gene
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Discovery of the white mutation in Drosophila melanogaster has broadly influenced our understanding of the mechanisms of inheritance. We recently discovered a role of the white gene in memory formation. Thus, the white ...
Brain natriuretic peptide decreases pulmonary artery pressure in rats with pulmonary hypertension
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
INTRODUCTION: B-type or Brain natriuretic peptide (BNP) was first isolated from the porcine brain, but it is primarily secreted from the cardiac ventricles in humans. As a cardiac hormone it has a physiologic regulatory ...
Diversity of progeny from a single colony of Salmonella typhimurium after 19 months in sealed agar stabs
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Recent studies at the Cancer Research Center revealed numerous mutations in Salmonella typhimurium that had been sealed in agar stab vials and stored for over forty years. The bacteria that were conserved in over 20,000 ...
Peptidomics of Arabidopsis thaliana
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Peptidomics is study of all the peptides in an organism, some of which are signaling molecules. Peptides are polymers of amino acids. For the purpose of this work, peptides are defined as proteins being less than 15 kDa ...
Environmental report actualization for the license renewal of the University of Missouri Research Reactor Center
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Licensing requirements for power as well as non-power reactors must address environmental concerns related to radioactive emissions. The purpose and need for the renewal of the operating license for the Missouri University ...
How do we know that we have Obsessive-Compulsive Disorder?
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
The brain is a network of neurons that control our pleasure, emotion, motivation and is important for all types of learning. The objective of the overall research in the OCD's group is to examine the changes in brain ...
Post-Translational modifications and the effects on protein identification through mass spectrometry
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Mass Spectrometry is an effective tool for protein identification. A typical process for protein identification is to break down a protein into smaller peptides and to determine the mass of each of these peptides. These ...
Synthesis and analysis of activated carbon briquettes as an adsorbent for natural gas
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Activated carbon has been used for many years for its adsorptive properties. These adsorptive properties are a result of its high surface area to density ratio. It achieves this through its activation process. During ...
Epithelial-mesenchymal transition of brain tumor cells is differentially regulated in response to dexamethasone
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
In the epithelial-mesenchymal transition of tumors, the loss of cohesivity and the migratory capability of cells determine the invasiveness and therefore the malignancy of the cancer. Understanding these biophysical ...
Analysis of Arabidopsis thaliana mutants defective in the oligopeptide transporter OPT3
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
The transport of peptides across membranes is a phenomenon found in both prokaryotes and eukaryotes as a method of obtaining amino acids, nitrogen, and carbon. Peptides can be transported by ATP-dependent transporters, as ...
Membrane permeability of Bovine Ooctyes to Propylene Glycol and the application to the improvement of Cryopreservation
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
In this study, the goal was to determine the permeability parameters of bovine oocytes for water (Lp) and Propylene Glycol (PPG) at temperatures of 30, 20, 10, and 5°C. By determining permeability parameters, we can model ...
The measurement of residual feed intake to determine feed efficiency of pregnant Hereford heifers
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
The large potential improvement in profitability is what makes feed efficiency such a studied and concerned topic in the beef industry today. Currently, no herd exists in the United States that has been selected solely for ...
Host-guest complexes to molecular encapsulation of hydrogen
(University of Missouri--Columbia. Office of Undergraduate Research, 2005)
Science has always been about man learning from and attempting to mimic nature. In supramolecular chemistry this possibility is evident due to particularly interesting architectures of natural shell-like containers such ...