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Selective modulation of estrogen receptors : 27-hydroxycholesterol is a negative allosteric modulator of er-beta activity and estradiol binding
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The estrogen receptors alpha (ER[alpha]) and beta (ER[beta]) are important regulators of development and growth in many major organ systems. In the ...
Molecular mechanisms of enzyme dysfunction in human phosphoglucomutase-1 deficiency
(University of Missouri--Columbia, 2019)
Human phosphoglucomutase-1 (PGM1) belongs to the [alpha]-D-phosphohexomutase superfamily, an ancient lineage of enzymes critical for carbohydrate metabolism. PGM1 catalyzes the interconversion of glucose-1-phosphate and ...
Characterization of 14-3-3 [chi] phosphorylation in phosphorus stress in Arabidopsis thaliana and investigation of acetyl-coA carboxylase regulation using quantitative mass spectrometry
(University of Missouri--Columbia, 2016)
Oilseed development involves coordination and regulation of a complex metabolic network for efficient production of storage compounds, including fatty acids, proteins, and carbohydrates. Recent advances in mass spectrometry ...
Bacterial ribosome conformational dynamics during translation termination and rescue
(University of Missouri--Columbia, 2017)
Hydrolysis of polypeptide from the ribosome is a critical step that must occur prior to the ribosome recycling phase of translation. Inability of cells to do so can result in translation inhibition and eventually leading ...
The musculoskeletal effect of exercise and soluble activin receptor type 2b in mouse models of osteogenesis imperfecta
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Osteogenesis Imperfecta (OI) is a heritable connective tissue disorder primarily due to mutations in the type I collagen containing tissues, such as ...
Making others happy : the best route to one's own happiness?
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] There are many positive psychology interventions whose aim is to help people improve their levels of happiness and well-being, some of which work ...
Structural studies of inhibition and resistance mechanism of EFDA, a human immunodeficiency virus reverse transcriptase inhibitor
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.]
Characterizing the roles of an Arabidopsis Epsin n-terminal homology domain protein in plant innate immunity
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The plasma membrane (PM) serves as a crucial point of contact between a plant cell and its environment. Localized at this critical interface are proteins ...
Investigating the role of arginine 21 in the structure and function of human [alpha]A-crystallin
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cataractogenesis in the eye lens occurs as a result of protein aggregation. Of the multiple mutations in [alpha]A-crystallins associated with the ...
A novel role for the ATP7A copper transporter in cancer
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is a trace metal with a ready capacity to gain or donate electrons. This property is harnessed by numerous enzymes to perform vital functions ...
Characterization of the effects of 3,3'-diindolylmethane (DIM) in the TRAMP mouse prostate cancer model and DIM's interaction with estrogen receptor signaling
(University of Missouri--Columbia, 2018)
3,3'- diindolylmethane (DIM) is an acid -derived compound formed during the digestion of indole-3-carbinol (I3C), which is one of the main compounds in cruciferous vegetables, such as broccoli, cabbage and kale. Studies ...
Dissecting water stress-induced molecular responses in the maize primary root
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Drought is an important environmental factor limiting crop growth and productivity. With additional pressures arising from population growth and global ...
Roles of clathrin-coated vesicle networks in plant immunity and development
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] For a plant cell, the plasma membrane (PM) is not only the interface with its environment but also a signaling platform. Proteins localized to the PM ...
The role of the P2X7 nucleotide receptor in salivary gland inflammation
(University of Missouri--Columbia, 2017)
Salivary gland inflammation is a hallmark of Sjogren's syndrome (SS), a common autoimmune disease characterized by lymphocytic infiltration and the consequent impairment of the salivary gland and loss of saliva secretion, ...
Biophysical characterization of the structure and flexibility of the E. Coli ribosome
(University of Missouri--Columbia, 2019)
At the discovery of ribosomes by George Palade in 1955 in the first image of the subcellular environment, he described them as "a particulate component of small dimensions (100 to 150 [alpha]) and high density". Subsequently, ...
The minimal primary structures of RNA aptamers selected to bind HIV-1 reverse transcriptase
(University of Missouri--Columbia, 2010)
Human Immunodeficiency Virus (HIV) reverse transcriptase (RT) is the most common molecular target of current HIV treatments. Oligonucleotide aptamers bind and inhibit the RNA- and DNA-dependent polymerization activities ...
Phage display peptides for breast cancer targeting
(University of Missouri--Columbia, 2010)
Cancer cell surfaces differ from healthy cell surfaces allowing the detection of cancer targets on the cell. Use of these targets combined with radiolabeled targeting vehicles results in sensitive imaging agents, with ...
Mass spectrometry-based seed allergen quantification and applications in seed quality assessment
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Incidences of food allergies have doubled in the past two decades, becoming a worldwide public health concern. Together, tree nuts and peanuts cause ...
Amyloid-beta toxicity in neurons and potential botanical compounds for prevention of Alzheimer's disease
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Alzheimer's disease (AD) is characterized by a progressive decline in memory and cognitive function together with increased oxidative stress in the ...
Monosaccharide-binding of cystic fibrosis pseudomonas aeruginosa: glycopolymer preparations, methods development and phenotype assessment
(University of Missouri--Columbia, 2014)