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The copper ATPases : intracellular trafficking and nervous system function
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is essential for life, as it participates as a cofactor in numerous enzymatic reactions including energy generation, antioxidant defense, ...
Secretory phospholipase A2-IIA in Alzheimer's disease and inflammatory responses in astrocytes
(University of Missouri--Columbia, 2009)
Alzheimer's disease (AD) is a progressive, fatal neurodegenerative disease marked with dementia. Secretory phospholipase A2-IIA (sPLA2-IIA) is an inflammatory protein known to have a role in the pathogenesis of multiple ...
Characterization of the effects of 3,3'-diindolylmethane (DIM) in the TRAMP mouse prostate cancer model and DIM's interaction with estrogen receptor signaling
(University of Missouri--Columbia, 2018)
is still not clear. In this dissertation, we hypothesize that DIM works through estrogen receptor (ER) signaling to inhibit prostate cancer. We focus on DIM's interaction with ER, as well as its effects on preventing advanced prostate cancer and weight gain...
Pretargeted cancer radioimmunotherapy and radioimaging using antibodies and antibody fragments
(University of Missouri--Columbia, 2018)
Over the last few decades, antibodies have become the mainstay of cancer diagnosis and therapeutics. In traditional radioimmunotherapy (RIT), tumor targeting antibodies are directly conjugated with radioisotopes and depending ...
Roles of post-Golgi vesicular trafficking components in plant growth and immunity
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] Delineating the molecular mechanisms of plant immunity can help inspire novel ways to engineer more resistant plants which could contribute to reducing crop loss due to pathogenic infection. The ...
Investigation of the initial steps of jasmonic acid biosynthesis and a study of differential regulation of the ribosomal association of mRNA transcripts in jasmonate-dependent wound response
(University of Missouri--Columbia, 2020)
of evidence to show that the production of JA precedes the transcription and translation of JA-induced transcripts, therefore there are likely post-translational modifications occurring that elicit activation of the pathway. Chapter II of this dissertation...
Single cell-type metabolomics of Medicago truncatula border cells and their roles in host-microbe interactions
(University of Missouri--Columbia, 2022)
Border cells are a specialized cell type surrounding the root apical meristematic region of many plant species, with the exception of the Brassicaceae family that possess characteristically different border-like cells. ...